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(A) In the first stage of our approach, we scored exhaustive lists of k-mers for network level conservation. Schematic examples for a nonconserved k-mer (AAAAAAA) and a highly conserved one (UGUGAUA) are given in the left and right graphics, respectively.
(B) In the miRNA discovery stage, seed k-mers are used to search the genome for conserved and stable stem-loops.
