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. 2026 Apr 14;123(16):e2523148123. doi: 10.1073/pnas.2523148123

Fig. 2.

A six-panel figure shows neurological function, cell density, infarction volume, and cytokine level in wild type and Trem2 knock out mice.

Trem2 deficiency reduces ischemic injury and poststroke neuroinflammation. (A) Experimental scheme of PT-induced stroke in Trem2 WT and KO mice followed by assessments of neurological function, infarction size, neuronal survival, microglial proliferation, and cytokine expression. (B) Neurological function was evaluated by the mNSS at 7 DPI (WT: n = 7; KO: n = 6). (C and D) Nissl staining and NeuN immunostaining at 7 DPI were used to quantify infarction volume and peri-infarction neuronal survival in WT and KO mice (n = 7). (E) Iba1 and EdU costaining was performed to quantify total and proliferating microglia, as well as the proportion of proliferating microglia in the peri-infarction zone between genotypes (n = 7). (F) ELISA of IL-1β, TNFα, IL-6, and IL-10 levels in defined brain regions of WT and KO mice (n = 5).