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. 2026 Apr 14;123(16):e2523148123. doi: 10.1073/pnas.2523148123

Fig. 5.

A six-panel figure shows experimental setup, mNSS score, infarction volume, neuronal survival, microglia proliferation, and lipid accumulation.

sGpnmb reverses the protective effects of Trem2 deficiency after PT-induced stroke. (A) Scheme of intracerebral recombinant sGpnmb or PBS injection into Trem2 WT or KO mice before PT stroke. (B) Neurological function assessed by mNSS at 7 DPI (n = 6). (C and D) Nissl staining (C) and NeuN immunostaining (D) at 7 DPI quantified infarction volume and peri-infarction neuronal survival across groups (C: n = 6; D: n = 5). (E) Iba1 and EdU costaining quantified total and proliferating microglia, and their proportion, in the peri-infarction zone (n = 5). (F) Gpnmb, Iba1, and BODIPY immunostaining assessed Gpnmb expression and lipid droplet accumulation in the peri-infarction zone (n = 5).