Table 2.

Interrupted time-series analyses of step and trend changes in pregabalin dispensing before and after PBS listing of pregabalin

	2 years pre PBS listing	2 years post PBS listing	Step changea	p	Trend changeb	p
			% (99% CI)c		% (99% CI)
Mean (SD) monthly N of pregabalin dispensed	81.7 (21.4)	188.5 (30.6)	26.3% (6.2%, 50.3%)	< 0.001	− 1.1% (− 2.4%, 0.2%)	0.024
Mean (SD) monthly % of pain medicines dispensings that were pregabalin	4.3 (0.7)	9.9 (2.0)	29.3% (1.5%, 64.9%)	0.009	0.8% (− 1.3%, 3.0%)	0.312
Mean (SD) monthly % of gabapentinoids that were pregabalin	81.8 (4.4)	92.2 (2.6)	13.9% (7.5%, 20.6%)	< 0.001	0.5% (0.1%, 0.9%)	0.002
Median (IQR) cost per pregabalin dispensing ($AUD)	113.9 (75.0, 128.0)	36.9 (31.8, 36.9)	− 61.8% (− 66.8%, − 56.1%)	< 0.001	0.2% (− 0.8%, 1.3%)	0.551

^aStep change immediately following listing of pregabalin on PBS

^bTrend change in two years following listing of pregabalin on PBS

^cPercentage change with 99% confidence intervals (99% CI)