Table 5.
Studies on urinary porphyrins in human populations exposed to moderate levels of hexachlorobenzene (HCB).
| Porphyrins | ||||||
| Author year/country (ref) | N | Period | Serum-HCB (range in ng/mL) | UP | CP | Comments |
| WORKERS | ||||||
| Morley 1973/Australia [6] | 54 | 1950's-60's | NA | NS | NS | only 1 worker with high UP |
| Burns 1974/USA [7] | 20 | 1973–74 | <1–310 | NS | NS | - |
| Currier 1980/USA [8] | 50 | 1974–7 | 3–1121 | NS | ↓ | ↓ CP if HCB > 200 |
| Selden 1999/Sweden [21] | 27 | 1980's | NA(9E/18NE) | NS | ↑ | ↑ CPIII in E vs NE |
| GENERAL POPULATION | ||||||
| NEONATES | ||||||
| Ozalla 2002/Spain [18] | 68 | 1997–99 | 0.4–21 | NS | ↓ | ↓ CPI and CPIII |
| ADULTS | ||||||
| Burns 1975/USA [20] | 120 | 1972 | 0–23 | NS | ↑ | - |
| This study/Spain | 242 | 1994 | 2–1616 | NS | ↓ | ↓ CPI and CPIII |
NA: not available. NS: no statistically significant difference. UP: uroporphyrins. CP, CPI and CPIII: coproporphyrins total, I and III. E/NE: number of subjects exposed/non-exposed