Fig. 9.

Construction of a prognostic risk model based on core targets of BPs exposure-induced tumorigenesis in KIRC. A Forest plot of univariate Cox regression analysis for the core targets. HR: hazard ratio, CI: confidence interval. B The least absolute shrinkage and selection operator (LASSO) Cox regression with core targets. C Coefficients of the 7 core targets. D Kaplan–Meier survival curves for overall survival in high- and low-risk groups. E The risk plot based on the prognostic risk model. The dashed line indicates the separation between low-risk and high-risk subgroups. F Box plot of survival status in high- and low-risk groups. G Time-dependent ROC curves based on the risk score. H Univariate and multivariate Cox regression of risk score and clinical features. I Nomogram model for predicting individual survival probabilities. J Calibration curve. K Decision curve analysis (DCA) plot