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. 2026 Apr 12;6:106046. doi: 10.1016/j.bas.2026.106046

Table 8.

Recommended HTS Preparations. All concentrations mentioned above can initially be administered via a peripheral IV line. However, for repeat doses of HTS with concentrations ≥5%, the use of a central IV line is recommended, if available. NS = Normal Saline; HTS = Hypertonic Saline.

Hypertonic Saline Preparations
Concentration 3% 5% 7.5%
Preparation 100 mL of NaCl at a concentration of 2 mEq/mL + 400 mL of NS 200 mL of NaCl at a concentration of 2 mEq/mL + 300 mL of NS 300 mL of NaCl at a concentration of 2 mEq/mL + 200 mL of NS
Dose 4-5 mL/kg 3-4 mL/kg 2 mL/kg