Table 2.
rs2743239-ACEs interaction analysis for college degree in UK Biobank among individuals with and without adverse childhood experiences (ACEs).
| Genotypes | Individuals without ACEs (n = 110,352) |
No. of outcome (%) | Individuals with ACEs (n = 17,219) |
p for interaction | |
|---|---|---|---|---|---|
| No. of outcome (%) | ORa (95% CI) | ORa (95% CI) | |||
| AA | 31,604/68,538 (46.11) | Ref | 3877/10,722 (36.16) | Ref | |
| TA | 14,989/32,608 (45.97) | 0.99 (0.97, 1.02) | 1902/5025 (37.85) | 1.08 (1.01, 1.16) | |
| TT | 1787/3831 (46.65) | 1.01 (0.95, 1.09) | 270/614 (43.97) | 1.44 (1.21, 1.71) | <0.0001 |
a
Odds ratio (OR) derived from logistic regression, adjusted for birth year, sex, number of full siblings, polygenic score for educational attainment, and the top 20 principal components.