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. 2025 Sep 30;99(4):1541–1547. doi: 10.1038/s41390-025-04418-x

Table 2.

The change of the parameters of the participant before and after treatment.

Variable Liposomal iron IV iron dextran p value
Before After Before After
Mean ± SD Mean ± SD Mean ± SD Mean ± SD

Hb

(g/dl)

 10.09 ± 1.38 11.68 ± 2.12 10.56 ± 1.58 11.17 ± 1.65 0.096
0.001** 0.065

RBCS

(cellx106/uL)

 3.68 ± 0.70 4.22 ± 0.89 3.98 ± 0.69 4.07 ± 0.77 0.756
0.001** 0.499

PLTs

(cell ×103/uL)

 272.33 ± 90.89 274.53 ± 107.43 319.03 ± 124.55 291.8 ± 162.43 0.135
0.885 0.30*

HCT

(%)

 31.16 ± 5.37 34.46 ± 7.41 33.27 ± 5.4 35.52 ± 4.94 0.504
0.003* 0.051

MCV

(fL)

 82.29 ± 7.02 85.02 ± 8.76 83.567 ± 5.56 85.17 ± 6.16 0.188
0.006* 0.032*

RDW-CV

(%)

 15.42 ± 1.26 16.61 ± 1.45 15.19 ± 1.33 16.31 ± 1.84 0.001**
0.001** 0.002*

Cr

(mg/dl)

 6.79 ± 2.37 7.37 ± 2.45 7.17 ± 2.19 7.72 ± 2.23 0.096
0.105 0.115

Hepecidin

(pg/mL)

 1357.52 ± 336.93 202.17 ± 127.01 801.17 ± 181.43 179.17 ± 99.48 0.756
0.001** 0.001**

Ferritin

(ng/ml)

 407.48 ± 421.37 241.14 ± 174.54 387.63 ± 344.64 398.8 ± 402.78 0.135
0.002* 0.184

Iron

(ug/dl)

 54.40 ± 24.92 78.39 ± 39.15 63.79 ± 16.56 80.66 ± 42.47 0.504
0.001** 0.014*

TIBC

(ug/dl)

 191.57 ± 82.05 252.3 ± 90.76 245.83 ± 48.64 286.87 ± 46.93 0.188
0.001** 0.002*

Transferrin

(mg/dl)

 166.07 ± 31.22 193.13 ± 39.02 178.73 ± 34.49 182.53 ± 43.05 0.001**
0.001** 0.226

Data are presented as mean ± SD, significant P < 0.05 (*) and highly significant P < 0.001 (**).

N.B Serum creatinine for hemodialysis patients was measured pre-dialysis.

Hb hemoglobin, RBCs red blood cells, PLTs platelets, HCT hematocrit, MCV mean corpuscular volume, RDW-CV red cell distribution width - coefficient of variation, Cr creatinine, TIBC Total iron binding capacity.