Table 2.
Duration of NSAID use among current users (use within a month) and risk of MI stratified by aspirin use and NSAID daily dose*
| Cases (%) | Controls (%) | OR (95%CI) | |
| Aspirin non users† | |||
| NSAID duration | |||
| Dura 0–30 days | 100 (28.2) | 481 (31.2) | 1.03 (0.81–1.30) |
| Dura 31–365 days | 149 (42.0) | 680 (44.1) | 1.04 (0.85–1.27) |
| Dura >365 days | 106 (29.8) | 381 (24.7) | 1.29 (1.01–1.65) |
| Aspirin current users† | |||
| NSAID duration | |||
| Dura 0–30 days | 46 (26.4) | 91 (28.8) | 0.94 (0.64–1.40) |
| Dura 31–365 days | 77 (44.3) | 126 (39.9) | 1.08 (0.78–1.50) |
| Dura >365 days | 51 (29.3) | 99 (31.3) | 0.90 (0.61–1.32) |
| NSAID low-medium dose‡ | |||
| NSAID duration | |||
| Dura 0–30 days | 92 (28.5) | 350 (31.3) | 1.04 (0.81–1.34) |
| Dura 31–365 days | 136 (42.1) | 484 (43.4) | 1.05 (0.84–1.32) |
| Dura >365 days | 95 (29.4) | 282 (25.3) | 1.30 (1.00–1.71) |
| NSAID high dose‡ | |||
| NSAID duration | |||
| Dura 0–30 days | 70 (27.2) | 269 (30.8) | 0.98 (0.73–1.31) |
| Dura 31–365 days | 110 (42.8) | 382 (43.8) | 1.10 (0.86–1.41) |
| Dura >365 days | 77 (30.0) | 222 (25.4) | 1.21 (0.90–1.64) |
* Duration of use was computed adding the periods of "consecutive" prescriptions, defined as an interval of less than one month between the end of supply of one prescription and the date of prescription of the subsequent one.
† Estimates are adjusted for sex, age, calendar year, anemia, smoking status, alcohol use, diabetes, hypertension, hyperlipidemia, BMI, RA, OA, prior cardiovascular disease, use of steroids, anticoagulants and paracetamol.
‡ Estimates are adjusted for sex, age, calendar year, anemia, smoking status, alcohol use, diabetes, hypertension, hyperlipidemia, BMI, RA, OA, prior cardiovascular disease, use of steroids, anticoagulants, aspirin and paracetamol. Cut-off values for dose in mg were: aceclofenac 100, acemetacin 120, apazone 600, diclofenac 75, etodolac 400, fenbufen 900, fenoprofen 1200, flurbiprofen 150, ibuprofen 1200, indomethacin 75, ketoprofen 100, mefenamic 1000, meloxicam 7.5, nabumetone 1000, naproxen 500, piroxicam 10, sulindac 200, tenoxicam 10, and tiaprofenic acid 450.