Figure 2.

Phylogenetic analysis of Chlamydomonas FKB12. A, Amino acid sequence of Chlamydomonas FKB12 compared to the FKBP12 protein from other representative organisms. Identical residues in at least nine of the 16 sequences are shaded in gray. Asterisks indicate residues from human FKBP12 that interact with rapamycin (Choi et al., 1996). B, Neighbor-Joining tree of FKBP12s. Bootstrap values from 1,000 replicates are shown. The scale bar corresponds to 0.1 estimated amino acid substitutions per site.