Table 5.
Distribution of genes across regions of high and low linkage disequilibrium
|
Assigned to region of
|
||||||
|---|---|---|---|---|---|---|
| Gene function (GO Term) | Annotated genes | Low LD | High LD | High-Low Ratio | χ2 | P-value |
| Amine metabolism | 167 | 51 | 45 | 0.88 | 0.14 | — |
| Biological process unknown | 648 | 165 | 190 | 1.15 | 10.45 | — |
| Biosynthesis | 447 | 130 | 129 | 0.99 | 2.43 | — |
| Carbohydrate metabolism | 212 | 74 | 70 | 0.95 | 0.76 | — |
| Catabolism | 357 | 112 | 90 | 0.80 | 0.02 | — |
| Cell adhesion | 335 | 110 | 78 | 0.71 | 0.93 | — |
| Cell cycle | 493 | 119 | 177 | 1.49 | 26.24 | <.00001 |
| Cell differentiation | 182 | 70 | 38 | 0.54 | 4.19 | .04 |
| Cell motility | 180 | 69 | 44 | 0.64 | 1.67 | — |
| Cell organization and biogenesis | 545 | 138 | 178 | 1.29 | 16.43 | .00005 |
| Cell proliferation | 876 | 254 | 267 | 1.05 | 8.25 | .004 |
| Cell surface receptor linked signal transduction | 670 | 256 | 149 | 0.58 | 10.99 | .0009 |
| Cell-cell signaling | 474 | 181 | 93 | 0.51 | 13.50 | .0002 |
| Cellular lipid metabolism | 253 | 87 | 60 | 0.69 | 1.03 | — |
| DNA metabolism | 366 | 74 | 139 | 1.88 | 35.37 | <.00001 |
| Immune response | 622 | 232 | 94 | 0.41 | 34.36 | <.00001 |
| Includes: humoral immune response | 154 | 54 | 19 | 0.35 | 10.60 | .001 |
| Includes: inflammatory response | 161 | 66 | 18 | 0.27 | 18.84 | .00001 |
| Intracellular signaling cascade | 604 | 212 | 150 | 0.71 | 1.84 | — |
| Intracellular transport | 263 | 56 | 95 | 1.70 | 19.61 | <.00001 |
| Ion transport | 213 | 81 | 42 | 0.52 | 5.84 | .02 |
| Lipid metabolism | 351 | 121 | 87 | 0.72 | 0.84 | — |
| Neurogenesis | 366 | 132 | 67 | 0.51 | 10.30 | .001 |
| Neurophysiological process | 384 | 149 | 78 | 0.52 | 10.35 | .001 |
| Includes: sensory perception | 191 | 82 | 41 | 0.50 | 6.75 | .009 |
| Organelle organization and biogenesis | 444 | 107 | 152 | 1.42 | 19.65 | <.00001 |
| Organic acid metabolism | 226 | 70 | 55 | 0.79 | 0.05 | — |
| Organogenesis | 805 | 294 | 162 | 0.55 | 16.49 | .00005 |
| Phosphorus metabolism | 368 | 99 | 120 | 1.21 | 8.51 | .004 |
| Programmed cell death | 350 | 111 | 85 | 0.77 | 0.21 | — |
| Protein localization | 174 | 39 | 60 | 1.54 | 9.76 | .002 |
| Protein metabolism | 1193 | 318 | 375 | 1.18 | 23.33 | <.00001 |
| Protein transport | 159 | 38 | 55 | 1.45 | 7.53 | .006 |
| Reproduction | 171 | 44 | 43 | 0.98 | 0.69 | — |
| Response to stimulus | 1346 | 472 | 290 | 0.61 | 14.78 | .0001 |
| Includes: response to DNA damage | 154 | 35 | 54 | 1.54 | 8.85 | .003 |
| Includes: response to external biotic stimulus | 431 | 158 | 56 | 0.35 | 30.62 | <.00001 |
| Includes: response to external stimulus | 825 | 303 | 154 | 0.51 | 23.53 | <.00001 |
| Includes: response to pest, pathogen or parasite | 415 | 154 | 53 | 0.34 | 31.42 | <.00001 |
| RNA metabolism | 208 | 41 | 71 | 1.73 | 15.33 | .00009 |
| Vesicle-mediated transport | 203 | 61 | 64 | 1.05 | 1.95 | — |
| All SWISS-PROT Entries Examined | 7520 | 2305 | 2045 | 0.89 | — | — |