Table 2.
Clinical symptoms and clinical interventions of the TRAR cases.
| Clinical symptoms/interventions | Reaction type | Non-serious | Serious |
|---|---|---|---|
| n = 194 | n = 37 | ||
| Clinical symptoms | ATR n = 221 | Localized rash accompanied by pruritus (166) | Rash + respiratory symptoms (8) |
| Rash + gastrointestinal symptoms (6)a | |||
| Generalized rash accompanied by pruritus (6) | |||
| Rash + throat dryness or cough (13) | Anaphylactic shock (5) | ||
| Facial or limb edema (5) | |||
| Drug-unresolved rash (4) | |||
| Rash + eyelid or facial edema (8) | |||
| FNHTR n = 8 | Fever with body temperature <39 °C (5) | Body temperature >39 °C + chills, nausea/vomiting or diarrhea (2) | |
| Fever with body temperature <39 °C + chills (1) | |||
| Others n = 2 | Abdominal pain (1) | Hematuria (1) | |
| Clinical interventions | ATR n = 221 | Corticosteroids (113) | Corticosteroids + antihistamines (14) |
| Corticosteroids + antihistamines (51) | Corticosteroids + antihistamines + epinephrine + oxygen therapy (5) | ||
| Antihistamines (12) | Corticosteroids + antihistamines + epinephrine (5) | ||
| Initiate close monitoring (9) | Corticosteroids + antihistamines + epinephrine + normal saline volume expansion (5) | ||
| Beta-agonist (2) | |||
| FNHTR n = 8 | Initiate close monitoring (1) | Paracetamol + corticosteroids + oxygen therapy (2) | |
| Paracetamol (2) | |||
| Corticosteroids (3) | |||
| Others n = 2 | Corticosteroids (1) | Corticosteroids + sodium bicarbonate (1) |
a
Respiratory symptoms including dyspnea, wheezing, tachypnea, laryngeal edema (with pharyngeal discomfort) and cough.