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. 2005 Dec 9;33(22):e186. doi: 10.1093/nar/gni189

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Center-break events in the evolution of the 17q11 palindrome. A precursor sequence is postulated to have undergone four independent center-break events to give rise to the structures in human group-A and -B, chimp and gorilla. AT repeat expansion/contractions and SNPs that subsequently accumulate within the repetitive AT tracts in each lineage are not shown. The mechanism by which the central asymmetric deletions are generated is described more in detail elsewhere (48,50).