A	Adenine
AAV6	Adeno-associated virus 6
ABEs	Adenine base editors
ANZCTR	Australia and New Zealand Clinical Trials Registry
BCL11A	B-cell lymphoma/leukemia 11A
BEs	Base editors
BT	β-thalassemia
C	Cytosine
Cas	Clustered regularly interspaced short palindromic repeats (CRISPR)-associated
CBEs	Cytosine base editors
ChiCTR	Chinese Clinical Trial Registry
CMN	CRISPR Medicine News
CRISPR	Clustered regularly interspaced short palindromic repeats
DSB	Double-stranded break
G	Guanine
gRNA	guide RNA
HCT	Hematopoietic cell transplant
HDR	Homology-directed repair
HPFH	Hereditary persistence of fetal hemoglobin
HSC	Hematopoietic stem cell
HSPC	Hematopoietic stem and progenitor cells
IHBDS	Institute of Hematology and Blood Diseases
indels	Insertions or deletions
LGMD	Limb–girdle muscular dystrophy
nCas9	Cas9 nickase
NHEJ	Non-homologous end joining
NIAID	National Institute of Allergy and Infectious Diseases
NIH	National Institutes of Health
PAM	Protospacer adjacent motif
pegRNA	prime-editing guide RNA
PKD	Pyruvate kinase deficiency
RT	Reverse transcriptase
SCD	Sickle cell disease
SCID	Severe combined immunodeficiency
T	Thymine
TDT	Transfusion-dependent β-thalassemia
X-CGD	X-linked chronic granulomatous disease
X-SCID	X-linked severe combined immunodeficiency
ZFN	Zinc-finger nuclease