Figure 8: Tumor progression trees inferred by ScisTree on scRNA data from control tumors sequenced by Seq-Well and Smart-seq2.

a. Tumor progression trees inferred by ScisTree from seqwell-control data (“Seq-Well”, left) and smartseq-control data (“Smart-seq2”, right). The clonal trees are labeled by the number of mutations that were inferred to have been acquired for the first time in the evolution of the tumor for each node/subclone.

b. An optimal alignment between Seq-Well and Smart-seq2 tree, “Alignment tree”, as determined by performing omlta. The clonal tree is labeled by the number of common mutations with concordant placement between Seq-Well and Smart-seq2 trees.