Table 2.
The main characteristics included in the study on treating nodular basal cell carcinoma.
| Author year |
Country | Study design | Number of cycles | Light intensity, and dose | Evaluation time | Intervention | Number of lesions | No. of patient |
Age | Gender (Male: Female) | CR | PR | Beauty effect rate | One-year survival rate | Three-years survival rate | Five-years survival rate | Recurrent rate | Incidence rate of adverse events |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peter Wolf 1992 (8) | Austria | single-arm | 1 | 100 mW/cm2 | 1-2 months | 20% ALA-PDT | 10 | 13 | N | 10/3 | 1/10 | N | N | N | N | N | N | N |
| K.SVANBERG1994 (21) | Sweden | single-arm | 1 | 110 mW/cm2 | The 1st, 3rd and 12th weeks | 20% ALA-PDT | 25 | 21 | 71(35-90) | 14/7 | 16/25 | N | 15/25 | N | N | N | N | N |
| Pier G. Calzavara-Pinton1995 (22) | Italy | single-arm | 1-2 | 630 nm,100 mW/cm2 | 1 months | 20% ALA-PDT | 30 | N | 65(24-87) | N | 15/30 | N | N | N | N | N | N | N |
| S.FIJAN. H.HONIGSMANN1995 (23) | Austria | single-arm | 1 | 50 - 300 mW/cm2 | 3-20 months | 20% ALA-PDT | 22 | 32 | N | N | 7/22 | N | N | N | N | N | N | N |
| A. M. Wennberg1996 (25) | Sweden | single-arm | 1 | 620-670 nm,150-200 mW/cm2,100 J/cm2 | 3 months | 20% ALA-PDT | 10 | 6 | 74.5(62–75 ) | N | 2/10 | N | N | N | N | N | N | N |
| ANA MARIA SOLER1999 (57) | Norway | single-arm | 1 | 550-700 nm,166 mW/cm2,75/100 J/cm2 | 3-6 months | 20% ALA-PDT | 119 | 58 | 36 ~ 86 | N | 113/119 | N | 103/119 | N | N | N | 6/119 | N |
| M.R.T.M.THISSEN2000 (58) | The Netherlands | single-arm | 1 | 630-635 nm,120 J/cm2 | 3 months | 20% ALA-PDT | 24 | 23 | N | N | 22/24 | N | 21/22 | N | N | N | N | N |
| A.M.SOLER2001 (29) | Norway | single-arm | 1-4 | 100-180 mW/cm2 | 3-6 months | ALA-PDT | 168 | 59 | N | N | 150/168 | N | N | N | N | N | 18/168 | N |
| I.WANG2001 (45) | Sweden | RCT | 1 | 635 nm,80 ±20 mW/cm2 | 4th, 8th week and 3-month follow-up | 20% ALA-PDT | 25 | 88 | N | 44/44 | N | N | N | N | N | N | 3/23 | N |
| M.HORN2003 (31) | Austria | single-arm | 1-2 | 570- 670 nm,50-200 mW /cm2,75 J/cm2 | 3 months | MAL-PDT | 45 | 94 | 68(32-93) | 57/37 | 45/52 | N | N | N | N | N | 4/28 | N |
| ALEKSANDR ITKIN2004 (59) | Massachusetts | single-arm | 1 | 417 nm,10mW /cm2 | 8 months | 20% ALA-PDT | 16 | 2 | N | N | 5/16 | N | N | N | N | N | N | N |
| Lesley E. Rhodes2004 (4) | England | single-arm | 1-2 | 570- 670 nm,50-200 mW /cm2,75 J/cm2 | 3 months | MAL-PDT | 53 | 52 | 69 (40-95) | 32/20 | 48/53 | N | 28/29 | N | N | N | 10/53 | 27/52 |
| Aleksander Sieron2004 (32) | Poland | single-arm | 2-12 | 635 nm, 100-125J/cm2 | N | 20% ALA-PDT | 35 | 35 | N | N | 21/35 | 10/35 | N | N | N | N | 7/35 | N |
| C. Vinciullo2005 (33) | Austria | single-arm | 1-2 | 570-670 nm,75 J/cm2 | 3,12,24 months | MAL-PDT | 33 | 36 | N | N | 27/33 | N | N | N | N | N | N | N |
| Lesley E. Rhodes2007 (4) | England | single-arm | 2/4 | 570-670 nm,75 J/cm2 | 5 years | MAL-PDT | 53 | 50 | 69(40-95) | N | 40/53 | N | 36/44 | N | N | N | 7/53 | N |
| Peter Schleier PdD2007 (46) | Germany | RCT | 1 | 120 J/cm2 | 6 months | MAL-PDT | 40 | 24 | 74(42-96) | 13/11 | 23/40 | 16/40 | N | N | N | N | 5/40 | 5/40 |
| ERM de Haas2008 (35) | The Netherlands | single-arm | 1 | 630 nm, 80 J/cm2 | 12 months | 20% ALA-PDT | 20 | 16 | 59(45-75) | 12/4 | 16/20 | N | 18/20 | N | N | N | N | N |
| K. Mosterd 2008 (11) | The Netherlands | RCT | 1 | 580-720 nm,100 mW/cm2,150 J/cm2 | 3 months | 20% ALA-PDT | 83 | 83 | N | N | 78/83 | N | N | N | N | N | N | N |
| Peter Foley 2009(62) | Australia | RCT | 2 | 570-670 nm,50-200mW/cm2,75 J/cm2 | 3/6 months | MAL-PDT | 75 | 66 | N | 47 / 19 | 55/75 | N | 42/43 | N | N | N | N | 60/66 |
| J. Lippert2010 (60) | Kralovs | single-arm | 2 | 980 nm | 6/12 months | MAL-PDT | 84 | 84 | N | N | 82/84 | N | N | N | N | N | N | N |
| F. Fantini2011 (36) | Italy | single-arm | 1-3 | 630 nm,37 J/cm2 | 6 months | MAL-PDT | 78 | 78 | N | N | 26/78 | N | N | N | N | N | N | N |
| Qiang Li2011 (37) | China | single-arm | 3 | 633 nm,113 J/cm2 | 6 months | MAL-PDT | 28 | N | N | N | 23/28 | N | N | N | N | N | N | N |
| R. Cosgarea2012 (48) | Romania | RCT | 2 | 37 J/cm2 | 3 months | 20% ALA-PDT | 17 | 32 | N | N | 15/17 | N | N | N | N | N | 2/17 | N |
| Marieke H. Roozeboom2013 (63) | The Netherlands | RCT | 1 | 150 J/cm2 | 5 years | 20% ALA-PDT | 83 | 83 | 64.0 (24-83) | 43/40 | N | N | N | N | N | N | 23/83 | N |
| Dora P Ramirez2014 (38) | Brazil | single-arm | 2 | 40±8 mW/cm2 | N | MAL-PDT | 151 | N | N | N | 112/151 | 37/151 | N | N | N | N | N | N |
| C.S. Haak2014(64) | Denmark | RCT | 2 | N | 12 months | MAL-PDT | 16 | 16 | N | N | 10/16 | N | N | N | N | N | 3/16 | N |
| S.H. Choi2016 (65) | South Korea | RCT | 1 | 632 nm,37 J/cm2 | 3 months | AFL-MAL-PDT | 19 | 18 | N N |
N N |
16/19 | N | N | N | N | N | 1/19 | N |
| 2 | MAL-PDT | 18 | 16 | 9/18 | N | N | N | N | N | 10/18 | N | |||||||
| M. Tarstedt 2016 (51) | Sweden | RCT | 2 | 37 J/cm2 | 6 months | 20% ALA-PDT | 19 | N | N | N | 15/18 | N | N | N | N | N | N | N |
| C.A. Morton2018 (53) | UK | RCT | 1-2 | 635 nm,37 J/cm2 | 5 years | BF-200 ALA-PDT | 28 | 21 | N | N | 25/28 | N | N | N | N | N | N | N |
| MAL-PDT | 28 | 21 | N | N | 21/28 | N | N | N | N | N | N | N | ||||||
| Adel Olasz 2018 (39) | Norway | single-arm | 3 | 37 J/cm2 | 6 months | MAL-PDT | 190 | N | N | N | 172/190 | N | N | N | N | N | N | N |
| Clara Gomez 2021 (44) | Spain | single-arm | 2-3 | 630 nm,90 J/cm2 | 3 years | MAL-PDT | 144 | 118 | N | 61/57 | 137/144 | N | 144/144 | 140/144 | 137/144 | N | N | N |
| Ana Gabriela Salvio2024 (61) | Brazil | single-arm | 1 | 150 J/cm2 | 1 months | MAL-PDT | 96 | 52 | N | N | 86/96 | N | N | N | N | N | N | N |
| Ana Gabriela Salvio2025 (13) | Brazil | RCT | 1 | 630 nm,125 mW/cm2,150 J/cm2 | 1 months | 20% ALA-PDT | 189 | 189 | 64.2 | N | 171/189 | N | N | N | N | 149/189 | N | N |
| MAL-PDT | 189 | 189 | 65 | N | 161/187 | N | N | N | N | 138/189 | N | N | ||||||
| Leore Lavin2025 (66) | UK | RCT | 2 | 633 nm,37 J/cm2 | 1-3 months | 20% ALA-PDT | 13 | 11 | N | N | 10/13 | N | N | N | N | N | N | N |
ALA, Aminolevulinic acid; MAL, Methyl aminolaevulinate; PDT, Photodynamic therapy; N, Not mentioned.