Table.

Comparative efficacy of the 6 currently available statin drugs

Statin drug (mg)
Cerivastatin	Atorvastatin	Simvastatin	Lovastatin	Provastatin	Fluvastatin	Cholesterol levels
(Baycol)	(Lipitor)	(Zocor)	(Mevacor)	(Pravachol)	(Lescol)	Total	LDL	LE⇑↑ >3 × ULN*
0.3	5	10	20	20	40	22%⇓	27%⇓	0.25%
0.4	10	20	40	40	80	27%⇓	34%⇓	0.50%
	20	40	80			32%⇓	41%⇓	1%
	40	80				37%⇓	48%⇓	2%
	80					42%⇓	55%⇓	2.3%

*LE↑ >3 × ULN = liver enzyme increase >3 times upper limit of normal.

Modified from Roberts WC. The rule of 5 and the rule of 7 in lipid-lowering by statin drugs. Am J Cardiol 1997;80:106–107. Used with permission.