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Heat map of NO• and cAMP effects on the expression of NO•-regulated cell cycle genes. Differentiated U937 cells were incubated with glutathione (GSH; 400 μM) or S-nitrosoglutathione (GSNO; 400 μM) in the absence or presence of dibutyryl-cAMP (Bt2cAMP; 100 μM). Color intensity reflects fold change from differentiated cells at 0 h; up-regulation is shown in red and down-regulation in green. Fold changes were computed from the mean results of seven independent microarray experiments.
