Table 2.
Fold change of induced gene expression in B lymphoblasts treated with ionophore A23187. Genes listed here showed a 2-fold increase or more in gene expression in at least one of the three B lymphoblasts cultured for 48 h with 200 nM A23187. Data are fold changes calculated from hybridization values in treated versus non treated cells for each one of the B lymphoblasts respectively (see additional file 1). For each functional group, the genes were ordered by using a program for gene clustering. *Genes basally expressed differently in the cell lines (see additional file 2).
| Accession no. | control | daughter's | Scott | Gene definition |
| Chemokines | ||||
| D90144 | 2.05 | 2.79 | 1.80 | LD78 alpha |
| M26383 | 12.28 | 15.78 | 8.70 | MONAP |
| D43768 | 11.58 | 30.28 | 11.87 | SCM-1* |
| NM002984 | 5.46 | 8.43 | 4.63 | SCYA4 |
| U83171 | 9.70 | 2.44 | 2.29 | macrophage-derived chemokine* |
| U02020 | 3.79 | 4.71 | 3.37 | PBEF |
| X13274 | 4.19 | 3.20 | 9.17 | IFN-gamma |
| D12614 | 2.83 | 3.91 | 3.01 | TNF-beta |
| Cell proliferation | ||||
| AB044548 | 7.36 | 1.83 | 1.77 | P/OKcl.6* |
| X79067 | 2.40 | 1.98 | 1.56 | ERF-1 |
| X59892 | 4.29 | 4.83 | 4.71 | IFN-inducible gamma 2 |
| AB021663 | 7.95 | 12.89 | 5.23 | leucine-zipper protein |
| D84224 | 7.47 | 10.92 | 7.44 | methionyl tRNA synthetase |
| X52560 | 4.32 | 4.10 | 3.70 | NF-IL6 |
| AF064105 | 3.44 | 3.00 | 2.67 | Cdc14B3 phosphatase |
| AF022375 | 2.86 | 2.22 | 2.63 | VEGF |
| X77366 | 2.66 | 2.51 | 2.42 | HBZ17 |
| M91196 | 2.02 | 3.70 | 3.47 | DNA-binding protein |
| J04076 | 3.67 | 3.88 | 3.41 | EGR2 |
| U09587 | 2.01 | 2.13 | 2.20 | glycyl-tRNA synthetase |
| U12767 | 3.84 | 4.00 | 7.02 | MINOR |
| U27655 | 3.70 | 1.76 | 3.60 | RGP3 |
| U88964 | -1.14 | 1.14 | 2.57 | HEM45* |
| D87116 | 1.67 | 1.79 | 2.71 | MAP kinase kinase 3b |
| Metabolism | ||||
| U08997 | 2.03 | 2.41 | 1.82 | glutamate dehydrogenase |
| X01630 | 12.51 | 17.87 | 15.17 | argininosuccinate synthetase |
| M55543 | 6.11 | 4.96 | 4.47 | GPB-2* |
| M37721 | 2.20 | 2.27 | 2.77 | peptidylglycine alpha-amidating monooxygenase |
| AF081195 | 2.48 | 3.98 | 2.18 | CalDAG-GEFII |
| U53347 | 2.05 | 2.21 | 2.25 | neutral amino acid transporter B |
| M77836 | 2.86 | 3.08 | 2.36 | pyrroline 5-carboxylate reductase |
| X05908 | 2.18 | 3.45 | 2.77 | Lipocortin* |
| X92720 | 2.05 | 2.10 | 2.34 | phosphoenolpyruvate carboxykinase |
| AK000379 | 2.82 | 2.91 | 3.10 | similar to asparagine synthetase |
| X76488 | 2.43 | 2.48 | 2.44 | lysosomal acid lipase* |
| S52784 | 3.36 | 3.86 | 4.85 | cystathionine gamma-lyase |
| U26398 | 1.98 | 3.69 | 2.77 | inositol polyphosphate 4-phosphatase |
| AF002020 | 1.03 | 1.33 | 3.00 | Niemann-Pick C disease protein |
| M11233 | 1.23 | 1.21 | 3.59 | cathepsin D* |
| Metallothionein family | ||||
| M13003 | 2.85 | 10.83 | 1.90 | metallothionein-I F* |
| K01383 | 3.62 | 4.60 | 3.90 | metallothionein-I A |
| D13365 | 2.74 | 2.46 | 2.36 | GIF |
| X64177 | 1.91 | 2.79 | 1.82 | metallothionein |
| M10942 | 1.93 | 2.49 | 2.17 | metallothionein-I E |
| Micellaneous | ||||
| M31516 | 5.63 | 4.00 | 3.57 | decay-accelerating factor |
| D90224 | 4.84 | 3.93 | 2.16 | GP 34* |
| M27492 | 2.28 | 3.60 | 3.07 | IL-1 receptor* |
| AF104032 | 2.43 | 3.06 | 2.83 | LAT1 |
| X03444 | 2.79 | 2.02 | 3.66 | lamin A* |
| U33017 | 1.90 | 2.62 | 1.56 | SLAM |
| U16954 | 1.97 | 2.35 | 2.81 | AF1q* |
| U64863 | 4.14 | 4.57 | 3.41 | PD-1* |
| Y14039 | 2.25 | 3.48 | 2.51 | CASH alpha* |
| U76248 | 2.47 | 2.81 | 2.68 | SIAH2 |
| M80899 | 2.13 | 1.33 | 2.69 | AHNAK* |