Table 3. Odds Ratios (ORs) and 95% Confidence Intervals (CI) for Associations between Targeted PFAS Measures in Dried Blood Spots and Childhood Acute Lymphoblastic Leukemia (ALL) in Los Angeles County, California (2000–2015).
Models were fit using a generalized linear model, with inverse-probability weighting and survey design-based standard errors. All models included maternal age at birth (< 25, ≥ 25 & < 35, ≥ 35 years) and insurance type used to pay for delivery of child (public, private, other). Quartiles are based on the distribution of controls. PFOA and PFOS were modeled categorically by quartiles and the detection of PFHxS, FOSA, PFPeA, and 6:2 FTS were modeled as dichotomous variables in the mutually adjusted models (n=276, p-value=0.69). P-values are from design-based ANOVA.
| Single PFAS Models | Mutually Adjusted PFAS Model | |||||
|---|---|---|---|---|---|---|
| Chemical (pg/g dried blood) | n | OR | 95% CI | p-value | OR | 95% CI |
| Continuous | ||||||
| Log2 PFOA | 335 | 1.15 | 0.84, 1.58 | 0.38 | ||
| Log2 PFOS | 340 | 1.12 | 0.85, 1.47 | 0.41 | ||
| Categorical | ||||||
| PFOA | 0.56 | |||||
| 2.14 – 1365.89 | 79 | --- | --- | --- | --- | |
| 1365.89 – 3136.46 | 82 | 1.10 | 0.27, 4.42 | 0.68 | 0.12, 3.71 | |
| 3136.47 – 5645.01 | 84 | 0.85 | 0.23, 3.09 | 0.47 | 0.09, 2.48 | |
| 5645.02 – 21569.07 | 90 | 1.64 | 0.44, 6.14 | 1.81 | 0.33, 9.88 | |
| PFOS | 0.31 | |||||
| 9.13 – 2058.09 | 84 | --- | --- | --- | --- | |
| 2058.10 – 5822.69 | 76 | 0.65 | 0.19, 2.23 | 1.07 | 0.24, 4.78 | |
| 5822.70 – 11481.99 | 85 | 1.43 | 0.42, 4.87 | 2.54 | 0.38, 16.80 | |
| 11482.00 – 43719.92 | 95 | 1.56 | 0.42, 5.73 | 1.63 | 0.17, 15.69 | |
| Binary (detect vs non-detect) | ||||||
| PFPeA | 323 | 1.75 | 0.57, 5.40 | 0.34 | 1.79 | 0.54, 5.93 |
| PFHxS | 344 | 1.99 | 0.71, 5.62 | 0.20 | 1.21 | 0.33, 4.43 |
| 6:2 FTS | 301 | 0.75 | 0.24, 2.38 | 0.62 | 0.91 | 0.27, 3.06 |
| PFOSA | 342 | 1.46 | 0.54, 3.93 | 0.46 | 0.52 | 0.11, 2.54 |