Table 4. Odds Ratios (ORs) and 95% Confidence Intervals (CI) for Associations between Non-Targeted PFAS Measures in Dried Blood Spots and Childhood Acute Lymphoblastic Leukemia (ALL) in Los Angeles County, California (2000–2015).
Models were fit using a generalized linear model, with inverse-probability weighting and survey design-based standard errors. All models included maternal age at birth (< 25, ≥ 25 & < 35, ≥ 35 years) and insurance type used to pay for delivery of child (public, private, other). Quartiles are based on the distribution of controls. PFAS were modeled continuously in the mutually adjusted models (n=86, p-value=0.10); C5HF9O3 and C13H2F24O2 were excluded due to collinearity.
| Single PFAS Models | Mutually Adjusted PFAS Model | |||||
|---|---|---|---|---|---|---|
| Chemical (pg/g dried blood) | n | OR | 95% CI | p-value | OR | 95% CI |
| Continuous | ||||||
| Log2 C4HF7O3 | 294 | 1.24 | 0.90, 1.71 | 0.32 | 5.04 | 1.08, 23.63 |
| Log2 C4HF9O4S | 289 | 1.06 | 0.84, 1.34 | 0.69 | 0.81 | 0.28, 2.36 |
| Log2 C5HF9O3 | 268 | 1.27 | 0.91, 1.77 | 0.27 | ||
| Log2 C9H2F16O2 | 265 | 1.26 | 0.86, 1.86 | 0.38 | 0.33 | 0.08, 1.39 |
| Log2 C14H2F26O2 | 207 | 1.60 | 0.98, 2.62 | 0.21 | 1.96 | 0.12, 33.30 |
| Log2 C15H2F28O2 | 196 | 1.51 | 0.89, 2.56 | 0.26 | 1.19 | 0.02, 80.30 |
| Log2 C13H2F24O2 | 175 | 0.99 | 0.51, 1.93 | 0.99 | ||
| Log2 C10HF19O5 | 172 | 1.23 | 0.96, 1.57 | 0.25 | 1.80 | 0.59, 5.53 |
| Log2 C16H8Cl2F6N2O2S | 292 | 1.17 | 0.82, 1.69 | 0.39 | 0.87 | 0.22, 3.43 |
| Categorical | ||||||
| C4HF7O3 | 0.87 | |||||
| 507.2 – 13559.8 | 71 | --- | --- | |||
| 13559.8 – 25823.6 | 70 | 1.23 | 0.30, 5.07 | |||
| 25823.7 – 43834.6 | 80 | 1.56 | 0.35, 6.92 | |||
| 43834.7 – 495276.0 | 73 | 1.79 | 0.38, 8.41 | |||
| C4HF9O4S | 0.36 | |||||
| 2214.7 – 60204.0 | 77 | --- | --- | |||
| 60204.1 – 119837.9 | 76 | 1.62 | 0.36, 7.29 | |||
| 119838.0 – 215860.5 | 73 | 3.17 | 0.77, 13.10 | |||
| 215860.6 – 3529999.0 | 63 | 1.04 | 0.23, 4.75 | |||
| C5HF9O3 | 0.57 | |||||
| 160.9 – 6845.5 | 65 | --- | --- | |||
| 6845.6 – 12058.0 | 68 | 0.85 | 0.17, 4.19 | |||
| 12058.1 – 22277.3 | 74 | 2.03 | 0.47, 8.67 | |||
| 22277.4 – 195076.1 | 61 | 1.24 | 0.29, 5.39 | |||
| C9H2F16O2 | 0.64 | |||||
| 3391.8 – 14742.4 | 66 | --- | --- | |||
| 14742.5 – 23662.7 | 71 | 0.53 | 0.13, 2.23 | |||
| 23662.8 – 37135.2 | 67 | 0.83 | 0.18, 3.87 | |||
| 37135.3 – 426198.9 | 61 | 1.28 | 0.32, 5.05 | |||
| C14H2F26O2 | 0.18 | |||||
| 2603.3 – 23780.0 | 42 | --- | --- | |||
| 23780.1 – 32951.8 | 46 | 4.90 | 0.77, 31.19 | |||
| 32951.9 – 46174.8 | 56 | 5.57 | 0.86, 36.07 | |||
| 46174.9 – 275222.0 | 63 | 5.94 | 0.90, 39.35 | |||
| C15H2F28O2 | 0.56 | |||||
| 2201.0 – 20623.3 | 45 | --- | --- | |||
| 20623.4 – 29365.7 | 45 | 1.75 | 0.37, 8.32 | |||
| 29365.8 – 39471.4 | 46 | 2.94 | 0.63, 13.81 | |||
| 39471.5 – 143211.9 | 60 | 1.79 | 0.37, 8.72 | |||
| C13H2F24O2 | 0.89 | |||||
| 10734.8 – 29827.9 | 39 | --- | --- | |||
| 29828.0 – 41803.7 | 41 | 2.05 | 0.31, 13.79 | |||
| 41803.8 – 53557.5 | 36 | 1.11 | 0.17, 7.11 | |||
| 53557.6 – 212811.1 | 59 | 1.39 | 0.23, 8.26 | |||
| C10HF19O5 | 0.01 | |||||
| 486.6 – 3738.6 | 45 | --- | --- | |||
| 3738.7– 9440.7 | 36 | 0.20 | 0.02, 1.82 | |||
| 9440.8 – 25537.5 | 43 | 0.41 | 0.05, 3.55 | |||
| 25537.6 – 516726.0 | 48 | 5.20 | 1.15, 23.56 | |||
| C16H8Cl2F6N2O2S | 0.28 | |||||
| 3834.0 – 60541.1 | 68 | --- | --- | |||
| 60541.2 – 119313.6 | 67 | 2.20 | 0.40, 12.01 | |||
| 119313.7 – 221887.9 | 84 | 3.73 | 0.89, 15.64 | |||
| 221888.0 – 946875.0 | 73 | 1.90 | 0.46, 7.90 | |||