Table 2. Significant Associations Between Resting-State ROI Connections and MOS_AP Learning.

Separate linear regression models were used to assess the association between the MOS_AP and the ROI connection. Age and MDS-UPDRS-III score were included as covariates. Unstandardized beta and standard error (SE), standardized beta, t-value, p-value, FDR-corrected p-value, and 95% confidence intervals (CI) are shown for each significant model. pFDR values are reported for ROI predictor only; covariates were not included in multiple-comparison correction.

Model	Unstandardized		STD Beta	t-value	p-value	p-value (FDR-corrected)	95% CI
	Beta	SE
Immediate Learning (Post Intervention 1 – Baseline 2)
Right Thalamus – Right Amygdala	0.144	0.052	0.619	2.787	0.016	0.031*	[0.031, 0.257]
Age	−0.007	0.003	−0.592	−2.593	0.024		[−0.012, −0.001]
MDS-UPDRS, Part III	0.000	0.002	−0.057	−0.264	0.796		[−0.004, 0.003]
Long-Term Retention (Post Intervention 2 – Baseline 2)
Right Thalamus – Right Amygdala	0.105	0.040	0.599	2.593	0.025	0.033*	[0.016, 0.193]
Age	−0.006	0.002	−0.675	−2.774	0.018		[−0.011, −0.001]
MDS-UPDRS, Part III	0.000	0.001	0.040	0.175	0.864		[−0.003, 0.003]
Left Caudate – Left Hippocampus	0.122	0.034	0.748	3.595	0.004	0.017*	[0.047, 0.196]
Age	−0.004	0.002	−0.496	−2.537	0.028		[−0.008, −0.001]
MDS-UPDRS, Part III	0.002	0.001	0.391	1.780	0.103		[−0.001, 0.005]
Left Thalamus – Left Hippocampus	0.094	0.031	0.644	3.056	0.011	0.044*	[0.026, 0.162]
Age	−0.003	0.002	−0.312	−1.443	0.177		[−0.007, 0.001]
MDS-UPDRS, Part III	0.001	0.001	0.148	0.688	0.506		[−0.002, 0.004]

Abbreviations: FDR = false-discovery rate; MDS-UPDRS = Movement Disorders Society – Unified Parkinson’s Disease Rating Scale; MOS_AP = anterior-posterior margin of stability; ROI = region of interest; STD = standardized

Significance indicted by * p< 0.05 (FDR-corrected).