Table 2. Demographics and clinicopathological characteristics of the studied OSCC cohort.

Variable		Total OSCC N=95	Tumor EBV status		Tumor EBV viral load*			Tumor HCMV status
			Negative	Positive	Negative	Low	High	Negative	Positive
			N=56	N=39	N=56	N=20	N=19	N=88	N=7
Sex	Male	76	44	32	44	18	14	70	6
	Female	19	12	7	12	2	5	18	1
		P	0.797		0.408			1.000
Age (median)	58<	43	21	2	22	10	11	40	3
	≥58	52	35	17	34	10	8	48	4
		P	0.094		0.331			1.000
Smoking	No	18	6	12	6	8	4	18	0
	Yes	68	43	25	43	12	13	63	5
	Former	9	7	2	7	0	2	7	2
		P	0.035		0.044			0.114
Alcohol	No	52	30	22	30	13	9	50	2
	Moderate	25	16	9	17	2	6	21	4
	High	18	10	8	9	5	4	17	1
		P	0.826		0.429			0.153
Histological grade	1	65	32	33	32	17	16	53	2
	2	16	12	4	12	2	2	17	3
	3	14	12	2	12	1	1	18	2
		P	0.015		0.078			0.175
Nuclear grade	1	55	30	25	30	12	13	53	2
	2	20	12	8	12	6	2	17	3
	3	20	14	6	14	2	4	18	2
		P	0.482		0.420			0.220
Tumor size	T 1/2	65	41	24	41	15	9	60	5
	T 3/4	30	15	15	15	5	10	28	2
		P	0.266		0.087			1.000
Nodal status	0	34	16	18	16	10	8	31	3
	1	50	36	14	36	7	7	46	4
	2	11	4	7	4	3	4	11	0
		P	0.020		0.081			0.604
Stage	I/II	29	16	13	16	10	3	26	3
	III/IV	66	40	26	40	10	16	62	4
		P	0.656		0.060			0.433
Recurrence	Negative	38	22	16	21	10	7	36	2
	Positive	57	34	23	35	10	12	52	5
		P	1.000		0.589			0.698

* EBV viral load categories were defined as negative, low (below the median), and high (above the median), based on values calculated as 2^(–ΔCt) x 200,000/10⁵ cells.