Table 3. Association of gene polymorphisms with demographic features .

Variables	Total		EBI3	EBI3	EBI3
	N=95		rs4740	rs4905	rs428253
			GG/GA/AA	AA/AG/GG	GG/GC/CC
Sex	Male	76	42/19/15	41/23/12	43/30/3
	Female	19	7/9/3	7/10/2	10/8/1
	P		0.157	0.187	0.936
Age	58<	43	21/12/10	21/14/8	23/18/2
	>58	52	28/16/8	27/19/6	30/20/2
	P		0.622	0.622	0.914
Smoking	Never	18	5/8/5	5/9/4	7/10/1
	Current	68	39/19/10	38/21/9	40/25/3
	Former	9	5/1/3	5/3/1	6/3/0
	P		0.122	0.326	0.549
Alcohol	No	52	24/18/10	24/22/6	28/23/1
	Low	25	14/6/5	13/7/5	14/8/3
	High	18	11/4/3	11/4/3	11/7/0
	P		0.769	0.481	0.217
Tumor EBV status	Negative	56	31/12/13	30/17/9	34/19/3
	Positive	39	18/16/5	18/16/5	19/19/1
	P		0.096	0.558	0.320
Tumor EBV viral load*	Negative	56	30/12/14	29/17/10	33/19/4
	Low	20	8/11/1	8/11/1	10/10/0
	High	19	11/5/3	11/5/3	10/9/0
	P		0.047	0.249	0.365
Tumor HCMV status	Negative	88	47/25/16	46/30/12	51/33/4
	Positive	7	2/3/2	2/3/2	2/5/0
	P		0.448	0.397	0.203
Histological grade	1	65	29/23/13	29/27/9	32/32/1
	2	16	11/3/2	11/3/2	13/0/3
	3	14	9/2/3	8/3/3	8/6/0
	P		0.299	0.298	0.001
Nuclear grade	1	55	29/19/10	25/23/7	30/24/1
	2	20	11/6/3	11/6/3	11/7/2
	3	20	12/3/5	12/4/4	12/7/1
	P		0.560	0.491	0.578
Tumor size	1/2	65	35/20/10	34/23/8	39/25/1
	3/4	30	14/8/8	14/10/6	14/13/3
	P		0.427	0.613	0.118
Nodal status	0	34	15/15/4	14/17/3	18/15/1
	1	50	28/9/13	28/12/10	29/18/3
	2	11	6/4/1	6/4/1	6/5/0
	P		0.082	0.144	0.827
Tumor stage	I/II	29	12/14/3	11/16/2	15/13/1
	III/I	66	37/14/15	37/17/12	38/25/3
	P		0.024	0.018	0.809
Recurrence	0	38	19/13/6	18/15/5	24/13/1
	1	57	30/15/12	30/18/9	29/25/3
	P		0.655	0.726	0.467

* EBV viral load categories were defined as negative, low (below the median), and high (above the median), based on values calculated as 2^(–ΔCt) x 200,000/10⁵ cells.