Figure 6. Classification of matrix metalloproteinases (MMPs).

Subgroup	MMP	Nomenclature	Main Matrix Substrates
Interstitial collagenases	MMP-1	Fibroblast collagenase	Fibrillar collagen (III > I)
	MMP-8	Neutrophil collagenase	Fibrillar collagen (I > III)
	MMP-13	Collagenase-3	Fibrillar collagen
Gelatinases	MMP-2	Gelatinase A	Collagen I, IV, V; gelatin
	MMP-9	Gelatinase B	Collagen IV, V; gelatin
Stromelysins	MMP-3	Stromelysin-1	Laminin, fibronectin, non-helical collagen
	MMP-10	Stromelysin-2	Similar to MMP-3
	MMP-11	Stromelysin-3	Collagen IV, gelatin, laminin
	MMP-7	Matrilysin	Similar to MMP-3
Membrane-type MMPs (MT-MMPs)	MMP-14	MT1-MMP	Collagen I, II, III; gelatin; activates MMP-2
	MMP-15	MT2-MMP
	MMP-16	MT3-MMP	Activates MMP-2
	MMP-17	MT4-MMP
Elastase-type MMPs	MMP-12	Metalloelastase	Elastin, fibronectin