Table 2. Clinical and demographic characteristics of the patients from TCGA-OTSCC cohort and the results of the Univariate and Multivariable Cox proportional hazards regression analyses.

Univariable Cox Regression
Clinicopathological Characteristics	Overall Survival					Disease-Free Survival
	n	p-value	HR	(95% CI)	PH	n	p-value	HR	(95% CI)	PH
CCNA2	128	0.02	1.0003	1.000-1.0005	0.407	128	0.02	1.000	1.00-1.001	0.424
Age	128	0.51	1.008	0.98-1.03	0.907	101	0.82	1.003	0.97-1.02	0.413
Sex
Male	83	Reference				68	Reference
Female	45	0.66	1.138	0.638-2.031	0.441	33	0.47	0.763	0.37-1.59	0.364
AJCC TNM Stage
I-II	34	Reference				30	Reference
III-IV	82	0.07	2.000	0.92 – 4.32	0.846	62	0.70	1.154	0.54-2.45	0.114
AJCC T Stage
I-II	67	Reference				58	Reference
III-IV	53	0.0004	3.018	1.62-5.61	0.949	37	0.12	1.711	0.86-3.39	0.077
AJCC N Stage
N0	51	Reference				45	Reference
I-II	63	0.09	1.725	0.90-3.28	0.894	47	0.55	1.236	0.60-2.50	0.869
Grade
I	17	Reference				13	Reference
II-III	111	0.26	1.794	0.63-5.05	0.008	88	0.16	2.738	0.65-11.41	0.701
Pharmaceutical Adjuvant
No	26	Reference				22	Reference
Yes	7	0.18	2.346	0.66-8.33	0,146	6	0.35	1.928	0.48-7.73	0.972
Radiation Adjuvant
No	16	Reference				13	Reference
Yes	19	0.21	2.313	0.61-8.72	0.994	17	0.16	3.015	0.63-14.22	0.571
Multivariable Cox Regression Model
Clinicopathological Characteristics	Overall Survival					Disease-Free Survival
	n	p-value	HR	(95% CI)	PH	n	p-value	HR	(95% CI)	PH
CCNA2	120	0.011	1.000	1.00-1.001	0.541	95	0.03	1.000	1.00-1.001	0.588
AJCC T Stage
III-IV	120	0.0003	3.18	1.69-5.98	0.946	95	0.099	1.787	0.89-3.56	0.082