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Oxidative damage to proteins in tissues of wild-type (blue bars) and mtDNA mutator (red bars) mice. (A) Relative amounts of carbonyl groups in liver total protein extracts, liver mitochondrial protein extracts, and heart total protein extracts at 40 weeks of age. (B) Aconitase enzyme activity in hearts of 12-, 25-, and 40-week-old mice. Bars show mean values, and error bars indicate SD. Asterisks indicate level of statistical significance: *, P < 0.05.
