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. 2026 Apr 15;13:1749788. doi: 10.3389/fmed.2026.1749788

Figure 11.

Panel A shows a heatmap with color-coded cell types on axes representing sender and receiver cells in the VISFATIN signaling network, with communication probabilities highlighted for specific cell pairs. Panel B is a bar graph displaying the importance of sender, receiver, mediator, and influencer roles for VISFATIN signaling among various immune and stromal cell types. Panel C presents a horizontal bar plot indicating the relative contribution of the NAMPT-INSR ligand-receptor pair. Panel D contains violin plots showing NAMPT and INSR expression across distinct cell types, color-coded and labeled. Panel E is a network diagram linking HSC-G-CSF and smooth muscle cells for the NAMPT-INSR pair, with circles for other cell types. Panel F is a circular plot depicting cell type-specific interactions for NAMPT-INSR, with arrows and color-coded segments for each cell population.

Characterization of the visfatin signaling pathway in MetS. (A) Communication strength between HSCs and smooth muscle cells. (B) Role assignment within the visfatin pathway. (C) Contribution analysis of the NAMPT–INSR pair. (D) Violin plots of NAMPT and INSR expression. (E) Network diagram and (F) chord diagram visualizing the communication mediated by NAMPT–INSR.