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. 2026 Apr 16;17:1722781. doi: 10.3389/fimmu.2026.1722781

Figure 2.

Three-panel figure presents forest plots summarizing risk factors for cutaneous immune-related adverse events (cirAEs). Panel A shows demographic factors with orange markers, panel B displays clinical features with blue markers, and panel C highlights biomarkers with green markers. Each panel lists risk factors, cirAE types, group percentages, odds ratios with confidence intervals, and corresponding studies. Dots and lines represent ORs and confidence intervals.

| (A) Odds ratios and percentages for demographic factors associated with cirAEs. (B) Odds ratios and percentages for clinical features associated with cirAEs. (C) Odds ratios and percentages for biomarkers associated with cirAEs. CirAEs, cutaneous immune-related adverse events. BP, bullous pemphigoid. BMI, body mass index. CTLA-4, cytotoxic T lymphocyte antigen-4. PD-1/PD-L1, programmed cell death-1/ligand-1. RCCEP, reactive cutaneous capillary endothelial proliferation. SJS, Stevens-Johnson syndrome. TVEC, talimogene laherparepvec. NSCLC, non-small cell lung cancer. ALC, absolute lymphocyte count. NLR, neutrophil-to-lymphocyte ratio. AEC, absolute eosinophil count. PLR, platelet-to-lymphocyte Ratio. ICIs, immune checkpoint inhibitors. -, Not mentioned in included study.