Skip to main content
. 2026 Apr 16;16:1796357. doi: 10.3389/fcimb.2026.1796357

Figure 4.

Panel A presents a heatmap comparing the positive rates of various respiratory pathogens in severe community-acquired pneumonia (SCAP) versus non-severe CAP, with significant rates highlighted in red. Panel B shows a correlation heatmap between pathogens and multiple clinical and demographic variables, coded by color gradient indicating Spearman correlation. Panel C depicts a boxplot comparing normalized reads between SCAP and non-severe CAP, showing a statistically significant difference. Panel D displays a bar chart with odds ratios and confidence intervals for selected risk factors in SCAP and non-severe CAP groups, indicating statistical significance for multiple variables.

Pathogen distribution and infection patterns in SCAP versus nsCAP patients. (A) Differences in pathogen detection rates between SCAP and nsCAP patients (only pathogens with detection rates ≥0.1% are shown, complete results are shown in Supplementary Figure 7). (B) Spearman correlation analysis between the detection of 25 clinically significant pathogens and clinical features. (C) Difference in M. pneumoniae normalized read counts between SCAP and nsCAP patients. (D) Multivariable-adjusted logistic regression analysis of SCAP versus nsCAP patients (only factors with p-value <0.05 are shown).