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. 2026 Apr 29;46(1):219. doi: 10.1007/s10792-026-04091-x

Table 3.

Subclassification of Stage 1 keratoconus based on steep keratometry

Epithelial thickness (µm)a Stage I
Subclassification A1
46 D > Steep K
(n = 105)
Stage I
Subclassification B1
48 D > Steep K ≥ 46 D
(n = 44)
p-value
Central 40.54 ± 5.55 (25–55) 38.52 ± 4.82 (30–55) .024*
Temporal 46.13 ± 4.24 (36–58) 45.75 ± 4.00 (37–55) .688
Superior 47.75 ± 4.15 (39–58) 48.39 ± 4.61 (41–60) .495
Nasal 47.01 ± 4.34 (39–58) 47.50 ± 3.05 (40–55) .319
Inferior 47.70 ± 5.34 (30–62) 47.64 ± 4.34 (33–56) .889
∆ Temporal—Central 5.59 ± 4.85 (− 6–25) 7.23 ± 5.11 (− 5–19) .029*
∆ Superior—Central 7.21 ± 5.17 (− 2–30) 9.86 ± 6.82 (− 5–24) .009*
∆ Nasal—Central 6.47 ± 5.13 (− 5–33) 8.98 ± 4.92 (− 5–21)  < .001*
∆ Inferior—Central 7.15 ± 5.60 (− 4–37) 9.11 ± 5.95 (− 6–21) .020*

1Based on stage I Steep K and refraction range definition of Amsler-Krumeich classification

aExpressed in mean ± standard deviation (minimum, maximum)

*Statistically significant level with U of Mann Whitney test for independent data