Table 4.

Summary of ROC curve analysis for epithelial thickness gradient variables. The table reports the area under the curve (AUC), 95% confidence intervals, optimal cut-off points (based on the Youden index), sensitivity, and specificity for each parameter

Variable	AUC	95% CI Lower	95% CI Upper	Optimal Cut-off*	Sensitivity	Specificity
∆ Temporal—Central	0.960	0.938	0.983	0.500	0.938	0.952
∆ Superior—Central	0.976	0.961	0.991	0.500	0.957	0.947
∆ Nasal—Central	0.967	0.948	0.986	2.500	0.899	0.973
∆ Inferior—Central	0.963	0.941	0.985	2.500	0.909	0.973
Mean ∆ET	0.975	0.958	0.992	1.125	0.957	0.973

AUC, area under the curve; CI, confidence interval; ET, epithelial thickness

^*Cut-off values were selected to maximize the sum of sensitivity and specificity (Youden’s J index) and may vary slightly depending on the distribution of values in the sample