Table 13.
Associations between CXCL8, MAP3K7, TNF/LTA, EXOC3L1, PROCR, and TRAF2 SNVs and response to treatment.
| Genetic model | Genotype/Allele | Non-responders n = 20 |
Responders n = 86 |
OR (95% CI) | p-value | AIC |
|---|---|---|---|---|---|---|
| CXCL8 rs2227306 | ||||||
| Codominant |
CT vs. CC TT vs. CC |
12 (60.0) 5 (25.0) |
44 (51.2) 16 (18.6) |
0.423 (0.109–1.640) 0.369 (0.078–1.759) |
0.213 0.211 |
104.536 |
| Dominant | TT + CT vs. CC | 17 (85.0) | 60 (69.8) | 0.407 (0.110–1.511) | 0.179 | 102.586 |
| Recessive | CT vs. CC + TT | 5 (25.0) | 16 (18.6) | 0.686 (0.217–2.163) | 0.520 | 104.273 |
| Overdominant | TT vs. CT + CC | 12 (60.0) | 44 (51.2) | 0.698 (0.260–1.879) | 0.477 | 104.160 |
| Additive | T | 22 (55.0) | 76 (44.2) | 0.627 (0.304–1.292) | 0.206 | 103.040 |
| MAP3K7 rs157432 | ||||||
| Codominant |
CT vs. CC TT vs. CC |
5 (25) 1 (5.0) |
30 (34.9) 1 (1.2) |
1.527 (0.501–4.652) 0.255 (0.015–4.327) |
0.456 0.344 |
105.087 |
| Dominant | TT + CT vs. CC | 6 (30.0) | 31 (36.0) | 1.315 (0.459–3.769) | 0.610 | 104.406 |
| Recessive | CT vs. CC + TT | 1 (5.0) | 1 (1.2) | 0.224 (0.013–3.735) | 0.297 | 103.667 |
| Overdominant | TT vs. CT + CC | 5 (25.0) | 30 (34.9) | 1.607 (0.952–4.852) | 0.400 | 103.928 |
| Additive | T | 7 (17.5) | 32 (18.6) | 1.086 (0.421–2.804) | 0.864 | 104.643 |
| TNF/LTA rs2229094 | ||||||
| Codominant |
TC vs. TT CC vs. TT |
8 (40.0) 2 (10.0) |
28 (32.6) 6 (7.0) |
0.673 (0.239–1.899) 0.577 (0.102–3.279) |
0.454 0.535 |
105.920 |
| Dominant | CC + TC vs. TT | 10 (50.0) | 34 (39.5) | 0.654 (0.246–1.737) | 0.394 | 103.948 |
| Recessive | TC vs. TT + CC | 2 (10.0) | 6 (7.0) | 0.675 (0.126–3.622) | 0.647 | 104.473 |
| Overdominant | CC vs. TC + TT | 8 (40.0) | 28 (32.6) | 0.724 (0.266–1.972) | 0.528 | 104.279 |
| Additive | C | 12 (30.0) | 40 (23.3) | 0.726 (0.348–1.514) | 0.393 | 103.961 |
| EXOC3L1 rs868213 | ||||||
| Codominant |
AG vs. AA GG vs. AA |
1 (5.0) - |
8 (9.3) - |
1.949 (0.230–16.538.230.538) - |
0.541 - |
106.238 |
| Dominant | GG + AG vs. AA | 1 (5.0) | 8 (9.3) | 1.949 (0.230–16.538.230.538) | 0.541 | 104.238 |
| Recessive | GG vs. AA + AG | - | - | - | - | - |
| Overdominant | AG vs. AA + GG | 1 (5.0) | 8 (9.3) | 1.949 (0.230–16.538.230.538) | 0.541 | 104.238 |
| Additive | G | 1 (5.0) | 8 (9.3) | 1.949 (0.230–16.538.230.538) | 0.541 | 104.238 |
| PROCR rs867186 | ||||||
| Codominant |
AG vs. AA GG vs. AA |
6 (30.0) 0 (0.0) |
27 (31.4) 2 (2.3) |
1.105 (0.383–3.191) - |
0.853 - |
105.792 |
| Dominant | GG + AG vs. AA | 6 (30.0) | 29 (33.7) | 1.187 (0.413–3.412) | 0.750 | 104.569 |
| Recessive | GG vs. AA + AG | - | 2 (2.3) | - | - | - |
| Overdominant | AG vs. AA + GG | 6 (30.0) | 27 (31.4) | 1.068 (0.370–3.080) | 0.903 | 104.657 |
| Additive | G | 6 (30.0) | 31 (18.0) | 1.269 (0.472–3.409) | 0.637 | 104.442 |
| TRAF2 rs10781522 | ||||||
| Codominant |
AG vs. AA GG vs. AA |
6 (30.0) 3 (15.0) |
35 (40.7) 11 (12.8) |
1.604 (0.538–4.787) 1.008 (0.239–4.258) |
0.397 0.991 |
105.868 |
| Dominant | GG + AG vs. AA | 9 (45.0) | 46 (53.5) | 1.406 (0.529–3.736) | 0.495 | 104.204 |
| Recessive | GG vs. AA + AG | 3 (15.0) | 11 (12.8) | 0.831 (0.209–3.307) | 0.793 | 104.605 |
| Overdominant | AG vs. AA + GG | 6 (30.0) | 35 (40.7) | 1.601 (0.561–4.570) | 0.379 | 103.868 |
| Additive | G | 12 (30.0) | 57 (33.1) | 1.139 (0.561–2.312) | 0.718 | 104.540 |