Table 3.
Univariate and multivariate cox regression analysis for OS
| Variable | Univariate | Multivariate (EDIC as continous) |
Multivariate (EDIC as categorical) |
|||
|---|---|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Age | 1.0 (0.9-1.03) | 0.7 | - | - | - | - |
| Sex | ||||||
| Female | Ref | - | - | - | - | |
| Male | 1.1 (0.6-2.1) | 0.7 | - | - | - | - |
| Smoking History | ||||||
| Never | Ref | |||||
| Former | 2.96 (0.4-21.8) | 0.2 | - | - | - | - |
| Current | 2.9 (0.39-21.2) | 0.2 | - | - | - | - |
| PS | ||||||
| 0-1 | Ref | |||||
| 2 | 1.2 (0.7-19) | 0.4 | - | - | - | - |
| Histology | ||||||
| Squamous | Ref | |||||
| Adenocarcinoma | 1.1 (0.6-1.9) | 0.6 | - | - | - | - |
| Other | 1.3 (0.6-2.6) | 0.4 | - | - | - | - |
| Tumor location | ||||||
| Upper lobes | Ref | |||||
| other | 1.0 (0.6-1.7) | 0.8 | - | - | - | - |
| Stage | ||||||
| IIIA | Ref | |||||
| IIIB-IIIC | 1.2(0.7-2.1) | 0.3 | - | - | - | - |
| Chemotherapy | ||||||
| Carboplatin-paclitaxel | Ref | |||||
| Other | 1.6 (0.9-2.6) | 0.08 | - | - | - | - |
| Chemotherapy scheme | ||||||
| Concomitant | Ref | |||||
| Sequential | 1.1 (0.6-1.9) | 0.6 | - | - | - | - |
| RT Technique | ||||||
| IMRT-VMAT | Ref | |||||
| 3DCRT | 1.3 (0.6-2.9) | 0.4 | - | - | - | - |
| CTV | 1 (0.9-1) | 0.7 | - | - | - | - |
| PTV | 1 (1-1.002) | 0.01 | - | - | - | - |
| Lung V20 | 1.05 (1.01-1.09) | 0.001 | - | - | - | - |
| MLD | 1.1 (1.04-1.2) | 0.003 | - | - | - | - |
| MHD | 1.07 (1.03-1.1) | 0.0001 | - | - | - | - |
| MHD <10 Gy | 2.6 (1.6-4.3) | 0.0001 | 1.8-1.0-3.2 | 0.03 | 1.9 (1.1-3.2) | 0.01 |
| LAD V15 | 1.01 (1.0-1.02) | 0.003 | - | - | - | - |
| LAD V15 <10% | 1.3 (0.8-2.2) | 0.1 | - | - | - | - |
| LAD V15 <47.5 | 1.01 (1.0-1.02) | 0.003 | - | - | 0.5 (0.2-0.9) | 0.02 |
| EDIC (continuous) | 1.6 (1.2-1.9) | 0.0001 | 1.4 (1.08-1.8) | 0.009 | - | - |
| EDIC (categorical) | ||||||
| EDIC ≥ 3 Gy | 2.1 (1.0-4.6) | 0.03 | - | - | - | - |
| EDIC ≥ 4 Gy | 2.5 (1.5-4.1) | 0.001 | - | - | - | - |
| EDIC ≥ 5 Gy | 3.4 (1.9-6) | 0.001 | - | - | 2.2 (1.2-4.1) | 0.008 |
| EDIC ≥ 6 Gy | 1.4 (0.4-4.7) | 0.5 | - | - | - | - |
| Esophageal Toxicity | ||||||
| < G2 | Ref | |||||
| ≥ G2 | 1.05 (0.6-1.7) | 0.8 | - | - | - | - |
Abbreviations: PS: performance status, RT: radiotherapy, IMRT: intensity modulated radiotherapya, VMAT: volumetric arc therapy, 3DCRT: conformal radiotherapy, MLD: meal lung dose, MHD, mean heart dose, LAD: left anterior descending coronary artery, EDIC: estimated dose to the immune cells