Table 4.
Univariate and multivariate cox regression analysis for PFS
| Variable | Univariate | Multivariate (EDIC as continous) |
Multivariate (EDIC as categorical) |
|||
|---|---|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Age | 0.9 (0.9-1.03) | 0.9 | - | - | - | - |
| Sex | ||||||
| Female | Ref | - | - | - | - | |
| Male | 1.0 (0.6-1.8) | 0.7 | - | - | - | - |
| Smoking History | ||||||
| Never | Ref | |||||
| Former | 1.0 (0.2-4.5) | 0.9 | - | - | - | - |
| Current | 1.0 (0.2-4.3) | 0.9 | - | - | - | - |
| PS | ||||||
| 0-1 | Ref | |||||
| 2 | 1.05 (0.6-1.7) | 0.8 | - | - | - | - |
| Histology | ||||||
| Squamous | Ref | |||||
| Adenocarcinoma | 1.1 (0.7-1.9) | 0.6 | - | - | - | - |
| Other | 0.6 (0.3-1.5) | 0.3 | - | - | - | - |
| Tumor location | ||||||
| Upper lobes | Ref | |||||
| other | 1.0 (0.6-1.6) | 0.9 | - | - | - | - |
| Stage | ||||||
| IIIA | Ref | |||||
| IIIB-IIIC | 1.3(0.8-2.2) | 0.2 | - | - | - | - |
| Chemotherapy | ||||||
| Carboplatin- | Ref | |||||
|
paclitaxel Other |
1.6 (0.9-2.7) | 0.053 | - | - | - | - |
| Chemotherapy scheme | ||||||
| Concomitant | Ref | |||||
| Sequential | 1.1 (0.7-1.9) | 0.5 | - | - | - | - |
| RT Technique | ||||||
| IMRT-VMAT | Ref | |||||
| 3DCRT | 1.0 (0.4-2.5) | 0.9 | - | - | - | - |
| CTV | 1 (1.0-1.003) | 0.04 | - | - | - | - |
| PTV | 1 (1.001-1.002) | 0.001 | 1.02 (1.01-1.003) | 0.006 | - | - |
| Lung V20 | 1.02 (0.9-1.06) | 0.2 | - | - | - | - |
| MLD | 1.1 (1.02-1.2) | 0.01 | - | - | - | - |
| MHD | 1.07 (1.03-1.1) | 0.0001 | - | - | - | - |
| MHD <10 Gy | 2.1 (1.3-3.5) | 0.002 | 1.06 (1.0.2-1.1) | 0.003 | ||
| LAD V15 | 1.01 (1.0-1.02) | 0.01 | - | - | - | - |
| LAD V15 <10% | 1.1 (0.7-1.9) | 0.4 | - | - | - | - |
| LAD V15 <47.5 | 2.4 (1.4-4.4) | 0.002 | - | - | - | - |
| EDIC (continuous) | 1.5 (1.1-1.9) | 0.001 | - | - | - | - |
| EDIC (categorical) | ||||||
| EDIC ≥ 3 Gy | 2.4 (1.1-5.1) | 0.01 | - | - | - | - |
| EDIC ≥ 4 Gy | 1.7 (1.0-2.7) | 0.02 | - | - | - | - |
| EDIC ≥ 5 Gy | 2.8 (1.6-5.1) | 0.001 | - | - | - | - |
| EDIC ≥ 6 Gy | 4.4 (1.5-12.3) | 0.005 | - | - | - | - |
| Esophageal Toxicity | ||||||
| < G2 | Ref | |||||
| ≥ G2 | 1.1 (0.7-1.8) | 0.5 | - | - | - | - |
Abbreviations: PS: performance status, RT: radiotherapy, IMRT: intensity modulated radiotherapya, VMAT: volumetric arc therapy, 3DCRT: conformal radiotherapy, MLD: meal lung dose, MHD, mean heart dose, LAD: left anterior descending coronary artery, EDIC: estimated dose to the immune cells