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Dose-dependent effect of metformin on odontogenic differentiation of DPSCs
| Variable | ODM | Metformin 500 µM |
Metformin 1000 µM |
p-value |
|---|---|---|---|---|
| ALP (U/mL) at day 3 | 28.0 ± 2.67b/c | 38.5 ± 2.26a/c | 20.5 ± 1.9a/b | 0.0002 |
| ALP (U/mL) at day 7 | 35.6 ± 2.08b | 52.1 ± 3.4c | 30.3 ± 1.34a/b | 0.0001 |
| ARS (µM) at day 7 | 1.74 ± 0.11b/c | 3.22 ± 0.15a/c | 2.05 ± 0.12a/b | 0.0001 |
| ARS (µM) at day 14 | 5.01 ± 0.45b/c | 6.81 ± 0.53a/c | 2.75 ± 0.3a/b | 0.0001 |
