Table 4.

Checking the quality of articles based on the ESA Protocol checklist*

Author	Screening question 1	Screening question 2	Sample Selection & Experimental Setup				Reagents & Cells							Sample Size		Random Allocation to groups	Blinding Allocation Concealment and Outcome Assessment	Attrition/Exclusions			score
	Q1	Q2	Q31	Q32	Q33	Q34	Q41	Q42	Q43	Q44	Q45	Q46	Q47	Q51	Q52	Q6	Q7	Q81	Q82	Q83
Khedmat et al. [4]	0	-	-	1	1	0.5	1	0	-	1	1	1	-	1	1	-	-	-	-	-	8.5/11
Omidi et al. [43]	1	-	-	1	1	1	1	0	-	1	1	1	0	1	1	-	-	-	-	-	10/11
Saberi et al. [44]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Saberi et al. [45]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11
Küçükkaya et al. [46]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Zhou et al [6]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Youssef et al. [47]	0	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9/11
Weekate et al. [48]	1	-	-	1	1	0.5	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9.5/11
Tomas Catal et al. [49]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Sultana et al. [50]	0	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9/11
Sismanoglu et al. [51]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Samyuktha et al. [52]	0	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9/11
Akbulut et al. [53]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Pinheiro et al. [54]	1	-	-	1	1	0.5	1	1	-	1	1	1	-	1	1	-	-	-	-	-	10.5/11
Pelepenko et al. [55]	0	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9/11
Pedorsa et al. [56]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11
Pedorsa et al. [57]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11
Pedano et al. [58]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Margunato et al. [59]	1	-	-	1	1	0.5	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9.5/11
Lee [60]	0	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9/11
Jovanovic et al. [61]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11
Hengameh et al. [62]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11
Gomes-Corn [63]	1	-	-	1	1	0.5	1	1	-	1	1	1	-	1	1	-	-	-	-	-	10.5/11
ASSADIAN et al. [64]	1	-	-	1	1	0.5	1	0	-	1	1	1	-	1	1	-	-	-	-	-	9.5/11
Dahake et al. [42]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Costa et al. [65]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11
Collado-Gonz et al. [66]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Bossù et al. [67]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11
Bortoluzzi e t al. [68]	1	-	-	1	1	0.5	1	1	-	1	1	1	-	1	1	-	-	-	-	-	10.5/11
Birant et al. [69]	1	-	-	1	1	1	1	0	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Attik et al. [70]	0	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	10/11
Agrafioti et al. [71]	1	-	-	1	1	1	1	1	-	1	1	1	-	1	1	-	-	-	-	-	11/11

Description: Yes=1, No=0, Partially=0.5, Not applicable= -