Fig. 4.

(a) Experimental points (’$x$’ markers) and simulated (solid lines) dependences of SBR on ICG concentration in Lipofundin, (b) simulated dependences of contrast on ICG concentration in biological tissue, and (c) simulated minimum detectable concentration in biological tissue depending on the optical density of the emission filter. Model parameters accounting for with AF (red lines) and without AF (blue lines): ICG concentration $N_{\mathrm{ICG}}=6.5\times {10}^{-11}$ to $6.5\times {10}^{-8}\mathrm{M}$, molar extinction coefficient $M=\mathrm{180,000}{\mathrm{M}}^{-1}·{\mathrm{cm}}^{-1}$, fluorescence quantum yield QY is 0.025 for Lipofundin and 0.13 for biological tissue, optical parameters ${\mu }_{a0}=0.02{\mathrm{cm}}^{-1}$ and ${\mu }_{s0}^{\prime }=20{\mathrm{cm}}^{-1}$ for Lipofundin, and ${\mu }_a=0.40{\mathrm{cm}}^{-1}$ and ${\mu }_s^{\prime }=15{\mathrm{cm}}^{-1}$ for biological tissues. Value ranges highlight the model parameter intervals described in Sec. 2.5.