Table 2. Detailed integrated summary of prioritized proteins across proteomic and genetic analyses.
For each prioritized protein, the table reports the corresponding proteomic assay, effect estimates and p-values from the protected-ε4, AD, and ε4-by-AD analyses, high-confidence loss-of-function burden testing results, and the best available plasma and cerebrospinal fluid Mendelian randomization results.
| Protein | ε4-Resilicncc | AD | ε4*AD | LoF Burden | MR plasma | MR CSF |
|---|---|---|---|---|---|---|
| DBI | −0.020 (p=1.36e,–04) |
0.008 (p=0.015) |
−0.015 (p=1.52e–05) |
0.712 (p=0.004) |
Wald: −0.016 (p=0.478) |
IVW: 0.020 (p=0.154) |
| BPNT1 | −0.028 (p=0.001) |
−0.000 (p=0.960) |
−0.025 (p=5.93e–05) |
0.524 (p=0.001) |
IVW: −0.006 (p=0.961) |
IVW: 0.016 (p=0.220) |
| PTEN | −0.021 (p=5.56e–04) |
−0.006 (p=0.103) |
−0.012 (p=0.003) |
1.235 (p=0.002) |
Wald: 0.163 (p=0.253) |
IVW: 0.006 (p=0.733) |
| LILRA5 | −0.028 (p=5.20e–06) |
0.002 (p=0.666) |
−0.017 (p=3.79e–04) |
−0.258 (p=0.109) |
IVW: −0.047 (p=0.013) |
IVW: 0.031 (p=0.010) |
| OMG | −0.031 (p=0.002) |
−0.040 (p=1.65e–l 1) |
−0.010 (p=0.145) |
0.104 (p=0.812) |
IVW: −0.213 (p=0.003) |
IVW: −0.010 (p=0.362) |
| EPHA1 | −0.029 (p=0.002) |
−0.004 (p=0.454) |
−0.015 (p=0.018) |
−0.045 (p=0.509) |
IVW: −0.119 (p=0.017) |
IVW: 0.019 (p=0.012) |
| PCDH10 | −0.023 (p=6.53e–04) |
0.002 (p=0.719) |
−0.018 (p=2.83e–04) |
−0.386 (p=0.407) |
IVW: −0.017 (p=0.026) |
IVW: 0.011 (p=0.584) |
| TREM2 | −0.025 (p=0.002) |
0.018 (p=0.001) |
−0.006 (p=0.346) |
0.931 (p=1.27e–09) |
IVW: −0.142 (p=3.75e–23) |
IVW:−0.125 (p=4.86e–05) |
| ACE | −0.018 (p=0.003) |
−0.014 (p=2.57e–04) |
−0.007 (p=0.111) |
0.171 (p=0.031) |
IVW: −0.145 (p=2.65e–12) |
IVW: −0.080 (p=0.008) |
| SELENOW | −0.068 (p=9.23e–13) |
−0.024 (p=6.24e–05) |
−0.026 (p=1.13e–04) |
0.045 (p=0.833) |
Wald: 0.086 (p=0.044) |
|
| NRBP1 | 0.020 (p=4.29e–05) |
0.007 (p=0.019) |
0.015 (p=1.80e–05) |
−1.213 (p=0.077) |
IVW: −0.088 (p=7.11e–04) |
IVW: −0.010 (p=0.596) |
| TPPP3 | −0.019 (p=1.95e–04) |
−0.013 (p=9.20e–05) |
0.001 (p=0.736) |
−0.515 (p=0.041) |
IVW: −0.028 (p=0.745) |
IVW: 0.049 (p=0.002) |
| CD247 | 0.018 (p=0.002) |
0.012 (p=6.73e–04) |
0.009 (p=0.024) |
−0.434 (p=0.003) |
Wald: 0.251 (p=0.019) |
IVW: 0.008 (p=0.539) |
| F2 | 0.008 (p=0.005) |
−0.003 (p=0.085) |
0.005 (p=0.020) |
0.550 (p=0.015) |
IVW: 0.083 (p=0.011) |
IVW: 0.008 (p=0.605) |
| VAT1 | −0.052 (p=3.83e–07) |
−0.074 (p=1.33e–31) |
0.015 (p=0.040) |
0.189 (p=0.441) |
IVW: −0.097 (p=0.003) |
IVW: 0.002 (p=0.887) |