Figure 3:

Correlations of humoral and cellular vaccine response with clinical CKD parameters prevaccination. (a) Linear inverse correlations between the fold increase in RSV-specific IgG or RSV-specific CD4 T cells and the UACR. Dots represent individual patients, orange-colored dots denote patients with immunosuppression. Lines correspond to the linear regression line with overlaid confidence intervals. (b) Linear correlation between fold increase in RSV-specific IgG and creatinine-derived eGFR. Dots represent individual patients. Lines correspond to the linear regression line with overlaid confidence intervals. (c) Predicted probability of being a vaccine responder based on a multivariate logistic regression model including log-transformed UACR as predictor and eGFR, serum urea and age as covariates. Due to the lack of predefined clinically relevant cutoffs, being a vaccine responder was defined as a composite of any measurable increase in RSV-specific CD4 T cells and IgG antibodies. The blue line represents a locally weighted scatterplot smoothing (LOESS) curve with other covariates set at the median, the light blue area displays the 95% confidence interval. Dots represent individual patients. CD, cluster of differentiation; Ig, immunoglobulin.