Table 4.

List of common genes suppressed (> 2-fold) in rat lung after 2 hr exposure to 2 and 5 ppm O₃.^a

Accession no.b	Gene symbolc	Gene namec	Fold changed
U87306	Unc5b	transmembrane receptor UNC5H2	−33.3
J04486	Igfbp2	insulin like growth factor binding protein-2 (IGFBP-2)	−15.5 (2 ppm) −5.0 (5 ppm)
D26439	Cd1d1	rat CD1 antigen precursor	−10.78
M63334	Cam4k	calcium-calmodulin dependent protein kinase IV	−10.40
M31838	Tacr2	substance K receptor	−6.42
L27057	Pde4a	cAMP phosphodiesterase 4A	−5.14
V01217	Actb	cytoplasmic beta-actin	−4.58
X06890	Rab4a	ras-related protein RAB4A	−4.28
U87305	Unc5a	transmembrane receptor UNC5H1	−3.97
M64092	Pkib	PKI-beta cAMP protein kinase inhibitor	−3.73
M94056	Dpep1	dipeptidase	−3.64
L34067	Gpc1	glypican-1 precursor	−3.33
X13817	Calm3	calmodulin	−3.21
Z22867	Pde3b	cAMP-dependent phsophodiesterase	−3.21
AB004454	Psen2	presenilin2	−3.10
M59859	Marcks	miristoylated alanine-rich C-kinase substrate	−2.93
J05155	Plcg2	phospholipase C gamma 2	−2.93
J03754	Atp2b2	PMCA, calcium-transporting ATPase plasma membrane form	−2.92
X06889	Rab3a	ras-related protein RAB3A	−2.60
J03806	Plcg1	phospholipase C gamma 1	−2.57
U69278	Epha3	Eph-related receptor tyrosine kinase (Rek4)	−2.54
M32748	Lif	leukemia inhibitory/cholinergic neuronal differentiation factor	−2.44
M60525	Vgf	VGF nerve growth factor, inducible	−2.40
U34841	Gprk5	G-protein-coupled receptor kinase 5	−2.31
U06069	Stxbp1	Sec1; syntaxin binding protein 1	−2.11
M94043	Rab38	RAB-related GTP-binding protein	−2.02

^aThe genes that were found down-regulated/suppressed and common to both 2- and 5-ppm–exposed rat lung are listed here.

^bAccession numbers derived from the NCBI Unigene database (http://www.ncbi.nlm.nih.gov/).

^cGene symbols derived from the Duke Integrated Genomics Database (https://dig.cgt.duke.edu/try_query.php).

^dFold suppression of gene expression. Fold changes in the expression of these genes were statistically significant by one-way ANOVA (p < 0.05).