Table 5.

List of induced (> 2-fold) genes that are unique to 2 or 5 ppm O₃.^a

Accession no.b	Gene symbolc	Gene namec	Fold changed
2 ppm O3
J03933	Thrb	thyroid hormone receptor beta, c-erbA-β	5.32
U73174	Gsr	glutathione reductase	5.21
L08447	Cd3z	T-cell receptor CD3 zeta subunit	4.37
L46791	Ces3	liver carboxylase precursor 10 (carboxylesterase 3)	3.95
J02650	Rpl19	60S ribosomal protein L19	3.51
X96394	Abcc1	multidrug resistance protein	2.70
D29766	Bcar1	FAK substrate p130	2.53
U49062	Cd24	signal transducer CD24	2.39
D16554	Ubb	polyubiquitin	2.25
5 ppm O3
X17163	Jun	c-jun AP1	5.26
M84203	Kcnc2	potassium channel protein (KshIII A)	5.20
D10862	Id1	inhibitor of DNA binding 1	4.33
M81855	Abcb1	multidrug resistance protein 1	2.74
D14051	Nos2	inducible nitric oxide synthase	2.61
U45965	Cxcl2	Mip-2 chemokine ligand 2	2.57
M86389	Hspb1	heat shock 27 kDa protein 1	2.55
L29232	Igf1r	IGF-1 receptor	2.50
D16237	Cdc25b	M-phase inducer phosphatase 2	2.48

^aGenes that were induced and unique to either 2- or 5-ppm–exposed rat lung are listed here. Accession numbers derived from the NCBI Unigene database (http://www.ncbi.nlm.nih.gov/).

^cGene symbols and names derived from the Duke Integrated Genomics Database (https://dig.cgt.duke.edu/try_query.php)

^dFold induction in gene expression. Fold changes in expression of these genes were statistically significant by one-way ANOVA (p < 0.05).