Table 6.
List of suppressed (> 2-fold) genes that are unique to 2 or 5 ppm O3.a
| Accession no.b | Gene symbolc | Gene namec | Fold changed |
|---|---|---|---|
| 2 ppm O3 | |||
| J02999 | Rab2 | ras-related protein RAB2 | 3.50 |
| L19698 | Rala | GTP binding protein (Ral A) | 3.11 |
| X07287 | Pkrcg | protein kinase C-γ | 2.86 |
| J03552 | Mug1 | plasma proteinase inhibitor | 2.81 |
| D85760 | Gna12 | guanine nucleotide-binding protein α-12 | 2.55 |
| M99567 | Plcb3 | phospholipase C β-3 | 2.45 |
| U00620 | Cfs2 | GM-CSF | 2.45 |
| M59980 | Kcnd2 | voltage-gated K+ channel protein | 2.18 |
| M83666 | Hck | Hck tyrosine protein kinase, p56 | 2.15 |
| AF020777 | Ptk2 | focal adhesion kinase | 2.04 |
| AF000300 | Lyn | lyn A tyrosine kinase | 2.03 |
| 5 ppm O3 | |||
| U46034 | Mmp11 | matrix metalloproteinase 11 | 3.61 |
| D55627 | Rbl2 | retinoblastoma-like 2 | 3.49 |
| M95738 | Slc6a11 | Na+/K+ dependent GABA transporter | 2.95 |
| M28647 | Atp1a1 | Na+/K+ ATPase α1 subunit | 2.42 |
| U93306 | Kdr | VEGFR-2 | 2.16 |
| M20637 | Plcd1 | phospholipase C delta 1 | 2.07 |
a
The genes that are found suppressed/down-regulated and unique to either 2- or 5-ppm–exposed rat lung are listed here.
b
Accession numbers from derived the NCBI Unigene database (http://www.ncbi.nlm.nih.gov/).
c
Gene symbols and name s derived from the Duke Integrated Genomics Database (https://dig.cgt.duke.edu/try_query.php).
d
Fold induction in gene expression. Fold changes in expression of these genes were statistically significant by one-way ANOVA (p < 0.05).