TABLE 3.
Mean changes from baseline by treatment group
| Placebo | Metformin | Lifestyle | P* | |
|---|---|---|---|---|
| n | 1082 | 1073 | 1079 | |
| Weight (kg) | ||||
| At 6 months | −0.32 ± 0.14 (−0.3) | −2.26 ± 0.14 (−2.4) | −6.73 ± 0.14 (−7.2) | <0.001 |
| At year 1 | −0.42 ± 0.17 (−0.4) | −2.72 ± 0.17 (−2.9) | −6.76 ± 0.17 (−7.2) | <0.001 |
| BMI (kg/m2) | ||||
| At 6 months | −0.12 ± 0.05 (−0.4) | −0.81 ± 0.05 (−2.4) | −2.41 ± 0.05 (−7.1) | <0.001 |
| At year 1 | −0.15 ± 0.06 (−0.4) | −0.97 ± 0.06 (−2.9) | −2.42 ± 0.06 (−7.1) | <0.001 |
| Fasting glucose (mg/dl) | ||||
| At 6 months | 0.20 ± 0.30 (0.2) | −3.99 ± 0.30 (−3.7) | −4.66 ± 0.30 (−4.4) | <0.001 |
| At year 1 | 0.63 ± 0.36 (0.6) | −4.18 ± 0.36 (−3.9) | −4.94 ± 0.36 (−4.6) | <0.001 |
| HOMA-IR at year 1 | 0.36 ± 0.13 (5.1) | −1.10 ± 0.13 (−15.3) | −1.59 ± 0.12 (−22.7) | <0.001 |
| Waist (cm) at year 1 | −0.69 ± 0.19 (−0.7) | −2.23 ± 0.19 (−2.1) | −6.36 ± 0.19 (−6.1) | <0.001 |
| Waist-to-hip ratio at year 1 | −0.002 ± 0.001 (−0.2) | −0.008 ± 0.001 (−0.9) | −0.021 ± 0.001 (−2.3) | <0.001 |
| Activity at year 1 (MET h/week) | 1.39 ± 0.72 (8.2) | 1.65 ± 0.72 (10.0) | 6.60 ± 0.72 (42.6) | < 0.001 |
Data are means ± SE (% of baseline); % baseline is derived by dividing the mean at baseline with the mean change.
*
P value represents the mean difference in characteristics among the three treatment groups using ANOVA.