TABLE 3.
Comparison between the Mouse and Rabbit cTnI Models
| Parameter | TG mouse (line 121)7 | TG rabbit (line 51) |
|---|---|---|
| Protein replacement (%) | 40% | 25% |
| Hypertrophy | No hypertrophy | Slight hypertrophy by 18 months |
| Pathology | No pathology or early mortality, although parous females showed cardiomyocyte hypoxia | Fibrosis and myocyte disarray in the apical and septal regions by 18 months; perinatal mortality in lines with high replacement |
| Cardiac function | +dP/dt is increased and −dP/dt is decreased in a working heart preparation | No physiologically significant changes |
| Ca2+ sensitivity | Increased | Increased |
| EKG | Normal | Normal |