Fig. 1.

General characterization of plasma exosomes from different human subjects. A Morphology of plasma exosomes observed by transmission electron microscopy (Scale bar: 500 nm). B Size distribution of plasma exosomes measured by nano-flow cytometry. C Statistical analysis of plasma exosome size across different groups (NC group, n=8; SLE group, n=6; N-SLE group, n=7; RA group, n=10). D Statistical analysis of plasma exosome particle concentration across different groups (NC group, n=8; SLE group, n=6; N-SLE group, n=7; RA group, n=10). E Nano-flow cytometry determining the proportion of CD63-positive plasma exosomes. F Difference of CD63-positive plasma exosomes proportions across the four groups (NC group, n=11; SLE group, n=16; N-SLE group, n=11; RA group, n=12). *, P < 0.05