Fig. 2.

Proteomic analyses of the differential expressed protein profiles in plasma exosomes from SLE and RA patients. A Principal component analysis (PCA) showing separation among NC, SLE, N-SLE, and RA groups based on plasma exosomal proteins. B Number of identified plasma exosomal proteins in NC, SLE, N-SLE, and RA groups. C Number of differentially expressed proteins across group comparisons. D-G Volcano plots displaying abundance differences of differentially expressed proteins between groups: (D) SLE vs. NC, (E) N-SLE vs. NC, (F) RA vs. NC, (G) SLE vs. N-SLE. H Top GO enrichment terms for plasma exosomal FAP and other differentially expressed proteins in active SLE (SLE vs. NC). I Top GO enrichment terms for plasma exosomal FAP and other differentially expressed proteins in inactive SLE (N-SLE vs. NC). J-L Comparison of protein-protein interaction (PPI) networks centered on FAP between groups: (J) SLE vs. NC, (K) N-SLE vs. NC, (L) SLE vs. N-SLE