Table 1.
Differentially expressed plasma exosomal proteins in sle patients versus healthy controls
| Gene ID | Accession number | log2FC | p-value | Regulation | Expression location | Subcellular localization | Function |
|---|---|---|---|---|---|---|---|
| KPRP | Q5T749 | 8.117 | 0.004 | Up | Keratinocyteand air follicle | Cytoplasm | Promoting tissue repair; Promoting tumor progression and metastasis |
| S100A7 | P31151 | 6.607 | 0.000 | Up | Widely expressed | Cytoplasm and ECM | Promoting cell proliferation and migration；Promoting inflammatory response and immune modulation |
| FAP | Q12884 | 6.013 | 0.001 | Up | Fibroblast and CAF | Cell membrane | Promoting tissue repair；Promoting tumor progression and metastasis |
| MME | P08473 | 5.776 | 0.000 | Up | Widely expressed | Cell membrane | Promoting the hydrolysis of bioactive peptides; Promoting cell proliferation and migration |
| PSMD6 | Q15008 | 5.347 | 0.031 | Up | Widely expressed | Cytoplasm | Promoting protein degradation; Promoting cell cycle progression |
| HSP90AB1 | P08238 | 5.25 | 0.001 | Up | Widely expressed | Cytoplasm and Nucleus | Promoting protein folding; Enhancing cellular stress signaling; Promoting tumor cell proliferation |
| SNED1 | Q8TER0 | 4.11 | 0.000 | Up | Widely expressed | Cell membrane and Cytoplasm | Promoting cell adhesion, migration, and proliferation |
| FCRL5 | Q96RD9 | 4.055 | 0.009 | Up | B cell and T cell | Cell membrane | Enhancing B cell signaling and immunoregulatory function |
| VASN | Q6EMK4 | 3.905 | 0.044 | Up | Widely expressed | Cytoplasm | Promoting angiogenesis；Promoting cell proliferation |
| CPQ | Q9Y646 | 3.627 | 0.003 | Up | Widely expressed | Cytoplasm | Promoting inflammatory and antioxidant effects；Promoting amino acid metabolism |
| POSTN | Q15063 | 2.525 | 0.001 | Up | Widely expressed | ECM | Promoting cell adhesion, migration, and proliferation；Promoting inflammation and tumorigenesis |
| FTL | P02792 | 2.496 | 0.017 | Up | Widely expressed | Cytoplasm | Promoting iron metabolism |
| DCXR | Q7Z4W1 | 1.519 | 0.032 | Up | Widely expressed | Cytoplasm | Enhancing glucose metabolism |
| PSMB8 | P28062 | 1.443 | 0.026 | Up | Widely expressed | Cytoplasm | Promoting protein degradation；Promoting antigen presentation |
| PSMA2 | P25787 | 1.361 | 0.049 | Up | Widely expressed | Cytoplasm | Promoting protein degradation |
| H2BC12 | O60814 | 1.342 | 0.002 | Up | Widely expressed | Nucleus | Promoting cell proliferation and differentiation |
| ATP5F1B | P06576 | 1.332 | 0.014 | Up | Widely expressed | Mitochondrion | Enhancing cellular energy metabolism |
| SFTPB | P07988 | 1.332 | 0.014 | Up | Alveolar type II cell | Cell membrane and Cytoplasm | Promoting alveolar stability |
| S100A12 | P80511 | 1.332 | 0.014 | Up | Widely expressed | Cytoplasm and Nucleus | Promoting inflammation；Promoting cell proliferation and differentiation |
| LGALS3BP | Q08380 | 1.239 | 0.033 | Up | Widely expressed | Cell membrane and Cytoplasm | Promoting cell proliferation and migratio；Inhibiting cell apoptosis |
| PSMA7 | O14818 | 1.225 | 0.019 | Up | Widely expressed | Cytoplasm | Promoting protein degradation |
| PSMB4 | P28070 | 1.122 | 0.030 | Up | Widely expressed | Cytoplasm | Promoting protein degradation；Promoting antigen presentation； |
| PSMB6 | P28072 | 1.102 | 0.036 | Up | Widely expressed | Cytoplasm | Promoting protein degradation；Promoting antigen presentation；Promoting cell cycle progression |
| IRAK4 | Q9NWZ3 | 1.089 | 0.000 | Up | Macrophage and Lymphocyte | Cytoplasm | Enhancing immune responses |
| PSMA6 | P60900 | 1.04 | 0.011 | Up | Widely expressed | Cytoplasm | Promoting protein degradation；Promoting antigen presentation；Promoting cell cycle progression |
CAF Cancer-associated fibroblast, ECM Extracellular matrix