Table 2.
Differentially expressed plasma exosomal proteins in N-SLE patients versus healthy controls
| Gene ID | Accession number | log2FC | p-value | Regulation | Expression location | Subcellular localization | Function |
|---|---|---|---|---|---|---|---|
| HSP90AB1 | P08238 | 7.692 | 0.000 | Up | Widely expressed | Cytoplasm and Nucleus | Promoting protein folding; Enhancing cellular stress signaling; Promoting tumor cell proliferation |
| ATP5F1B | P06576 | 6.287 | 0.000 | Up | Widely expressed | Mitochondrion | Enhancing cellular energy metabolism |
| RGN | Q15493 | 5.301 | 0.025 | Up | Widely expressed | Cytoplasm and Nucleus | Promoting signal transduction and cell proliferation；Promoting cell growth |
| PRG2 | P13727 | 4.719 | 0.022 | Up | Eosinophil and Skin | Cytoplasm and ECM | Enhancing immune responses |
| VASN | Q6EMK4 | 4.051 | 0.038 | Up | Widely expressed | ECM | Promoting angiogenesis；Promoting cell proliferation |
| FCRL5 | Q96RD9 | 3.963 | 0.009 | Up | B cell and T cell | Cell membrane | Enhancing B cell signaling and immunoregulatory function |
| FTL | P02792 | 2.385 | 0.011 | Up | Widely expressed | Cytoplasm | Promoting iron metabolism |
| SFTPB | P07988 | 2.258 | 0.046 | Up | Alveolar type II cell | Cell membrane and ECM | Promoting alveolar stability |
| CPQ | Q9Y646 | 2.199 | 0.040 | Up | Widely expressed | Cytoplasm | Promoting inflammatory response and immune modulation |
| S100A12 | P80511 | 2.015 | 0.038 | Up | Widely expressed | Cytoplasm and Nucleus | Promoting inflammation；Promoting cell proliferation and differentiation |
| MME | P08473 | 1.521 | 0.005 | Up | Widely expressed | Cell membrane | Promoting the hydrolysis of bioactive peptides; Promoting cell proliferation and migration |
| SAA2 | P0DJI9 | 1.521 | 0.005 | Up | Widely expressed | Plasma and ECM | Enhance immune responses; Promoting cell proliferation |
| FAP | Q12884 | 1.521 | 0.005 | Up | Fibroblast and CAF | Cell membrane | Promoting tissue repair；Promoting tumor progression and metastasis |
| POSTN | Q15063 | 1.437 | 0.011 | Up | Widely expressed | ECM | Promoting cell adhesion, migration and proliferation；Promoting inflammation and tumorigenesis |
| SPP2 | Q13103 | 1.08 | 0.000 | Up | Widely expressed | ECM | Promoting cell proliferation; Promoting bone formation |
| PSMB8 | P28062 | 1.013 | 0.005 | Up | Widely expressed | Cytoplasm | Promoting protein degradation；Promoting antigen presentation |
| PSMB4 | P28070 | 0.937 | 0.016 | Up | Widely expressed | Cytoplasm | Promoting protein degradation；Promoting antigen presentation； |